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Th17细胞的起源及其分化发育研究进展 被引量：6

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摘要 Th17细胞是近年来发现的一种Th细胞亚型,其以特异性分泌IL-17A为特征。在鼠类,Th17细胞和Foxp3+的调节性T细胞可能来源于共同的前体细胞,人类Th17细胞来源存在争议,可能来源于CD161+CD4+T细胞。Th17细胞的分化发育存在正性调节和负性调节机制,多种细胞因子和转录因子相互作用,共同调节Th17细胞的分化发育。人类的Th17细胞来源和分化发育具有特异性,对人类Th17细胞特性的研究为治疗人类感染和自身免疫性疾病提供新的方向。
作者 葛伟 雷革非 孙若鹏
机构地区 山东大学齐鲁医院小儿内科
出处 《现代免疫学》 CAS CSCD 北大核心 2011年第6期521-524,共4页 Current Immunology
关键词 TH17细胞 分化 细胞因子 转录因子
分类号 R392.12 [医药卫生—免疫学]
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参考文献25

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二级参考文献22

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共引文献5

同被引文献66

  • 1蔡凯,梁勇,张南征,陈复兴.IFN-DC的研究进展[J].现代免疫学,2009,29(1):80-84. 被引量：2
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  • 3蒋宇光,林洪生.肿瘤的发生与进化论的关系[J].实用肿瘤学杂志,2006,20(2):133-136. 被引量：6
  • 4孙楠,赵翔,罗全,刘顺寿.Ⅱ期非小细胞肺癌术后辅助化疗疗效分析[J].实用肿瘤学杂志,2007,21(2):150-151. 被引量：1
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引证文献6

二级引证文献23

现代免疫学
2011年 第6期

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