血小板活化特异性标志物PAC-1和CD62p与急性脑梗死病情严重程度的相关性被引量：13

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摘要目的探讨急性脑梗死(acute cerebral infarction,ACI)患者血小板膜糖蛋白(glycoproteinⅡb/Ⅲa,GPⅡb/Ⅲa)纤维蛋白原受体PAC-1和P选择素(P-Selectin,CD62p)与ACI患者病情严重程度的相关性。方法采用流式细胞仪技术分别检测58例ACI患者急性期(<7 d)外周血PAC-1和CD62p含量,同时采用Barthel指数和NIHSS量表评分法对ACI患者进行神经功能学评分,并选取20名健康人作为对照组进行参考值测定。结果与对照组(0.22±0.13;4.21±1.11)相比,ACI患者PAC-1含量(0.92±0.40)和CD62p含量(7.07±3.07)在急性期(<7 d)显著升高(P<0.05;P<0.05),且与ACI患者病情严重程度成正相关(P<0.05;P<0.01)。结论 PAC-1和CD62p与ACI患者病情严重程度呈正相关。早期检测PAC-1和CD62p水平对于预防ACI发生、评估病情轻重以及判断预后有着重要的意义。

作者张炘段传志李铁林龙霄翱何旭英谭峰方美凤黄彪

机构地区南方医科大学珠江医院神经外科广东神经外科研究所广州中医药大学附属佛山中医院神经内科

出处《中国神经精神疾病杂志》 CAS CSCD 北大核心 2011年第11期698-701,共4页 Chinese Journal of Nervous and Mental Diseases

基金广东省医学科学技术研究基金项目(编号:WSTJJ 20051101430103590927157)

关键词 PAC-1 CD62P ACI 病情相关性

分类号 R743.3 [医药卫生—神经病学与精神病学]

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