基于多组分多维向量归一的中药复方“总量”药动学评价模式的创新与思考

Innovation and thoughts on"total amount"pharmacokinetic evaluation pattern on Chinese materia medica formulae

中药药动学研究是中药现代化研究链条的重要组成部分,在创新中药及现代复方中药研发中发挥着极其重要的作用,但目前尚缺乏符合中药自身特点的药动学研究方法。概述现有中药药动学研究现状,提出了中药复方"总量"药动学的概念,以期能够起到抛砖引玉的作用,共同促进中药药动学研究水平的提高。

The pharmacokinetic study on Chinese materia medica （CMM） is an inalienable part of the chain in CMM modernization and plays an important role in the research and development of CMM novel drug and modern CMM formulae. However, nowadays the researching method and system that are consistent with the specific characteristics of CMM,i.e.,multiple-components and targets,is still lacking.This review makes a brief summary of our recent developments on the pharmacokinetic exploration of CMMs.A tentative idea about the＂total amount＂pharmacokinetics of CMM has been proposed in order to promote its pharmacokinetic development.