摘要
目的:探讨姜黄素(curcumin)对高原缺氧大鼠认知功能障碍的预防作用。方法:将30只成年雄性SD大鼠随机分为健康对照组、模型组(Model组)、姜黄素[按体重60mg/(kg.d)]治疗组(curcumin组)。采用Morris水迷宫实验方法检测缺氧后大鼠学习记忆功能变化,同时检测脑片水平的LTP变化。结果:(1)模型组大鼠寻找平台的潜伏期明显长于对照组,具有统计学意义(P<0.05),姜黄素组寻找平台的潜伏期相对于模型组显著缩短(P<0.05)。撤离平台后,模型组大鼠在平台所在象限的停留时间明显短于对照组(P<0.05),姜黄素干预后大鼠在平台所在象限的停留时间较模型组显著延长(P<0.05)。(2)给予HFS刺激后各组兴奋性突出后电位(fEPSP)斜率较前明显增加,均可持续1h以上,与模型组比较缺氧组HFS刺激后fEPSP斜率明显减小(P<0.05),姜黄素可减轻缺氧所致的fEPSP斜率减小(P<0.05)。结论:姜黄素可改善慢性缺氧大鼠认知功能障碍,但其具体机制尚有待于进一步研究。
Objective: To investigate the effects of curcumin on cognitive deficits induced by hypobaric hypoxia. Methods: 30 male Sprague-Dawley rats (200± 20 g) were randomly divided into three groups with 10 rats in each group: Control group, Model group and Curcumin group. Severe cognitive deficits were detected by the water maze task. Hippocampal LTP was measured by electrophysiol- ogy method. Results: Hypobaric hypoxia can cause severe cognitive deficits, and curcurnin could attenuate hypobaric hypoxia-induced cognitive deficits. LTP inhibition in hippocampus caused by hypobaric hypoxia were markedly improved by administration of curcumin for 4 weeks. Conclusions: Curcumin exhibits therapeutic potential for hypobaric bypoxia-induced cognitive deficits.
出处
《现代生物医学进展》
CAS
2011年第22期4236-4239,共4页
Progress in Modern Biomedicine
关键词
高原缺氧
姜黄素
认知功能障碍
Hypobaric hypoxia
Curcumin
Cognitive deficits