IL-18、hs-CRP、脂联素在代谢综合症和高血压病患者外周血清的变化及意义

Detection on sero IL-18,Adiponectin,and hs-CRP of the patients with hypertension and metabolism syndrome

目的:探讨代谢综合症和高血压病患者外周血清IL-18、脂联素及hs-CRP水平变化及其临床意义。方法:采用放射免疫法检测尿微量蛋白、血胰岛素水平,采用乳胶增强免疫比浊法法检测hs-CRP水平,采用ELISA法检测IL-18和脂联素水平。结果:与正常对照组比,高血压病组和MS组IL-18、hr-CRP、血糖、胰岛素水平明显升高(P<0.05),脂联素水平明显降低。IL-18水平与BMI、腰围、尿微量蛋白呈正相关,与HDL呈负相关(P<0.05),logistic分析表明,IL-18水平最显著影响因素是MB(IOR=1.230,P<0.05)。结论:IL-18在高血压病和MS患者表现不同程度的升高,并与MS诊断指标密切相关,可作为病情进展及疗效的指标。

Objective： To study the changes of levels of serum interleukin-18, high-sensitivity C-reactive protein and adiponectin in patients with hypertension or metabolism syndrome and its clinical significance. Methods： The levels of insulin and micro-albuminuria were tested by RIA. The level of serum high-sensitivity C-reactive was detected by irnmunoturbidi- metric Test. The levels of inter- leukin-18 and adiponectin were detected by ELISA. Results： The levels of the interleukin-18, hs-CRP, plasma glucose, insulin were sig- nificantly increased in hypertension and MS groups, and the level of adiponectin decreased markedly as compared to control group （P 〈 0.05）. The level oflL-18 was positively correlated with BMI, waistline and micro-albuminuria （P 〈 0.05）, but negatively correlated with HDL-c （P 〈0.05）. The Logistic regression analysis showed that BMI was the most significant factor influencing IL-18 （OR=1.230, P 〈 0.05）. Conclusion： The level of IL-18 increases in hypertension and MS groups and it is closely related with the assessment indicators of MS. Thus, it may be considered as an indicator that reflects the disease variety and efficacy.