Gal-4蛋白在大肠癌中的表达及其临床意义

The expression of Gal-4 protein and its clinical significance in colorectal cancer

目的探讨Gal-4蛋白在大肠癌中的表达及其临床意义。方法分别收集83例和31例石蜡包埋的大肠癌和正常大肠组织。免疫组化检测Gal-4蛋白在大肠癌及正常大肠组织中的表达。统计分析Gal-4蛋白表达变化与大肠癌临床参数之间的相关性。结果 Gal-4蛋白在大肠癌中的表达明显下调。此外,下调表达的Gal-4蛋白明显与大肠癌的分化程度、肿瘤大小、淋巴结转移及Duke分期相关。结论 Gal-4表达下调可能是大肠癌进展的一个恶性标志物。

Objective To explore the expression of Gal-4 protein and its clinical significance in colorectal cancers（CRCs）. Methods 83 CRC and 31 normal colorectal paraffin-embedding samples were collected and the expression of Gal-4 protein was detected in these samples by immunohistochemistry examination. The correlation between Gal-4 expression and clinical pathological features of CRCs was analyzed. Results Decreased Gal-4 expression appeared in CRCs. Furthermore, reduced Gal-4 protein expression was closely associated with the differentiation degree, T classification, lymphonode metastasis, and Duke＇s stage of CRC. Conclusion The decreased Gal-4 protein expression may be an malignant biomarker of CRC progression.