锌对细胞增殖、分化的影响

Zinc on cell proliferation and oifferentiation

锌对细胞的增殖、分化有重要的作用，调节DNA的合成和有丝分裂。在分子水平上，锌是很多蛋白质如细胞信号传导途径中的生化酶和转录因子的组成结构。锌可以调节细胞信号的识别、第2信使的代谢、蛋白激酶和蛋白磷酸酯酶的活性，刺激或抑制转录因子的兴奋性，同时锌还可能作为第2信使参与细胞的信号调节。

Zinc is essential for cell proliferation and differentiation, especially for the regulation of DNA synthesis and mitosis. On the molecular level, it is a structural constituent of a great number of proteins including enzymes of cellular signaling pathways and transcription factors. Zinc can modulate cellular signal recognition, second messenger metabolism, protein kinase and protein phosphatase activities. It may stimulate or inhibit activities of transcription factors,and it may as well be used as a second messenger involved in cell signaling regulation.