长春西汀治疗糖尿病周围神经病变疗效观察

Vinpocetine Treatment Diabetic Peripheral Neuropathy

目的观察长春西汀治疗糖尿病周围神经病变的疗效。方法选择2010年1月～2011年6月我院收治的糖尿病周围神经病变患者76例,全部患者采取随机数字表法随机分为治疗组和对照组各38例,所有患者均给予糖尿病饮食及降糖药物治疗,并控制饮食,适当运动。两组同时给予维生素B110mg,甲钴胺500μg,肌肉注射,每日1次,连用4周。其中治疗组在上述基础上给予长春西汀注射液30mg+生理盐水500mL,静脉滴注,每日1次,连用4周。比较两组的疗效及使用安全性情况。结果治疗4周后,在对照组治疗的基础上应用长春西汀后,治疗组的总有效率明显高于对照组,差异有显著性(P<0.05),但两组的显效率、有效率分别比较,差异不明显(P>0.05)。两组患者治疗前后肝肾功能未见明显损害,无明显不良反应发生。结论长春西汀治疗糖尿病周围神经病变疗效确切,能明显改善患者的症状、体征,值得广泛推广和应用。

Objective To observe the effect of vinpocetine treatment diabetic peripheral neuropathy.Methods All of 76 cases diabetic peripheral neuropathy were randomly divided into treatment group and control group, each group 38 cases. All patients were treated with diabetic diet and hypoglycemic drugs and diet, adequate exercise. Two groups were given vitamin B10mg, methylcobalamin 500 μg, intramuscular injection, once daily for 4 weeks. Treatment group based on the above given Vinpocetine 30mg ＋ saline injection 500mL, intravenous infusion, once daily for 4 weeks. The efficacy and safety of using were compared. Results After 4 weeks of treatment, the treatment group received treatment based on the application of vinpocetine, the total efficiency of the treatment group was significantly higher, the difference was significant （P 〈 0.05 ） than the control group. Two groups patients had no significant damage to liver and kidney function before and after treatment, no significant adverse reactions. Conclusion Vinpocetine treatment diabetic peripheral neuropathy is effective, and can significant improve symptoms and signs, should be widely promoted and applied.