O-季铵化-N,N-双烷基壳聚糖的单分子膜性质研究

Study on monolayer of O-quaternary ammonium-N,N-dialkyl chitosan

采用自制的季铵化试剂环氧丙基乙基三甲基氯化铵醚,制备3个不同烷基化长度的O-季铵化-N,N-双烷基壳聚糖(QADCS),用FTIR、EA和1H NMR对产物进行表征,并试验其单分子膜性质。结果表明,所制得的QADCS可以形成稳定的单分子膜,并且QADCS单分子膜的崩溃压、极限分子面积及最大压缩模量随着侧链长度的增长而增大,其中O-季铵化-N,N-双十二烷基壳聚糖单分子膜的凝聚力最强。为进一步研究QADCS的自组装性质及载药性能提供依据。

Three kinds of O-quaternary ammonium-N,N-dialkyl chitosan（QADCS）with different alkylation lengths were prepared by a self-developed quaternary ammonium reagent,glycidyl ethyl trimethyl ammonium chloride ether.The products were characterized by FTIR,EA and 1H NMR.The monolayers of the synthetic products were studied.It shows that QADCS can form stable monolayers.The collapse pressure（πc）,limiting molecular area（Aex）and maximum compressibility modulus（Cs-1,max）of the QADCS monolayers increase with the hydrophobic side-chain length,and the monolayer of O-quaternized ammonium-N,N-dilalkyl chitosan is the most cohesive.The research provides a basis for studying the self-assembly properties and drug-loading performances of QADCS.