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化学-酶法耦合制备拆分β-萘乙醇

The chemical-enzymatic preparation and resolution of β-naphthyl alcohol
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摘要 通过化学-酶相耦合的方法,成功制备出e.e.值>99%的S-β-萘乙醇,使其光学纯度达到了制备R-2-萘乙胺的要求。研究中以β-萘乙酮为原料,经硼氢化钠还原得到外消旋的β-萘乙醇。经过酶催化动力学拆分,β-萘乙醇中R型底物100%全转化为酯,S构型底物型被保留,这样体系中S构型底物的e.e.值达到近100%。本文还考察了若干因素对酶催化动力学拆分过程的影响,并最终确定了酶催化动力学拆分β-萘乙醇制备S-β-萘乙醇的最适条件:反应温度45℃,溶液为甲苯,底物浓度为100 mmol/L。 A preparation method of high purity S-β-naphthyl alcohol with chemical-enzymatic process was reported.S-β-naphthyl alcohol was obtained with the kinetic resolution of rac-β-naphthyl alcohol（hydrogenized from β-naphthyl ketone）,with an e.e.value near 100%.Several influence factors on the enzymatic resolution process were studied,and the optimized operation arguments were determined.
作者 陈永军 徐刚 程咏梅 吴坚平 杨立荣
机构地区 浙江大学玉泉校区化学工程与生物化工系生物工程研究所
出处 《化工进展》 EI CAS CSCD 北大核心 2011年第12期2704-2707,共4页 Chemical Industry and Engineering Progress
关键词 S-β-萘乙醇 化学-酶法 β-萘乙酮 动力学拆分 S-β-naphthyl alcohol chemistry-enzyme coupling method β-naphthyl ketone kinetic resolution
分类号 O625.3 [理学—有机化学]
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参考文献11

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化工进展
2011年 第12期

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