摘要
以L-酪氨酸为原料,六步法合成左旋甲状腺素钠。对左旋甲状腺素钠合成的关键步骤——偶联反应的催化剂进行了改进,考察了偶联反应催化剂用量、溶剂用量、反应温度、反应时间等因素对反应的影响。工艺经改进后,偶联收率达60.5%,比文献报道提高了18.5%,6步反应总收率为22.5%,比文献值提高了11.1%。
Levothyroxine sodium was synthesized from L-tyrosine as raw material by six-step reactions.The catalyst in the key step of coupling reaction was improved.Some factors of coupling reaction were analyzed including the effect of amount catalyst,solvent amount,reaction temperature and reaction time.Under the optimal reaction conditions,the yield of coupling reaction could reached up to 60.5%,which was about 18.5% higher than before,the total yield of levothyroxine sodium could reached up to 22.5%,which was about 11.1% higher than before.
出处
《化工进展》
EI
CAS
CSCD
北大核心
2011年第12期2743-2746,共4页
Chemical Industry and Engineering Progress
基金
常州市工业科技攻关项目(CE20090019)
关键词
左旋甲状腺素钠
合成
偶联反应
催化
levothyroxine sodium
synthesis
coupling reaction
catalysis