1Hiller D, Sanglard D, Morschhauser J. Overexpression of the MDR1 gene is sufficient to confer increased resistance to toxic compounds in Candida albicans [J]. Antimicrob Agents Chemother,2006,50(4) : 1365-1370.
2de Micheli M, Bille J, Schueller C, et al. A common drug-responsive element mediates the upregulation of the Candida al- bicans ABC transporters CDR 1 and CDR2,two genes involved in antifungal drug resistance[J]. Mol Microbiol, 2002,43 (5) 1197-121.
3Prasad R,De Wergifosse P,Goffeau A,et al. Molecular cloning and characterization of a novel gene of Candida albicans, CDR1 conferring multiple resistance to drugs and antifungals [J]. Curr Genet, 1995,27(4) :320-329.
4Sanglard D, Ischer F, Monod M, et al. Susceptibilities of Can- dida albicans multi-drug transporter mutants to various anti- fungal agents and other metabolic inhibitors[J]. Antimicrob Agents Chemother, 1996,40(10) : 2300-2305.
5Marichal P, Koymans L, Willemsens S, et al. Contribution of mutations in the eytochrome P450 14alpha-demethylase (Ergll p,Cyp51 p) to azole resistance in Candida albicans[J]. Microbiology, 1999,145(Pt 10) :2701-2713.
6White TC, Marr KA, Bowden RA. Clinical cellular and molecu- lar factors that contribute to antifungal drug resistance[J]. Clin Microbiol Rev, 1998,11 (2) :382-384.
8Kelly SL, Lamb DC, Kelly DE,et al. Resistance to fluconazole and cross-resistance to amphotericin B in Candida albicans from AIDS patients caused by defective sterol delta 5,6-desat- uration[J]. FEBS Lett, 1997,400 ( 1 ) : 80-82.
9Kumamoto CA. Candida biofilms[J]. Curr Opin Microbiol, 2002,5(6) :608-610.
7Ghannoum MA, Kuhn DM. Voriconazole-better chances for patients with invasive mycoses[ J]. Eur J Med Res, 2002,7 ( 5 ) :242-256.
8CAGGIANO G, CORETTI C, BARTOLOMEO N, et al. Candida Bloodstream Infections in Italy: Changing Epidemiology during 16 Years of Surveillance[ J]. Biomed Res Int,2015,2015:256580.
9MORII D,SEKI M, BINONGO JN, et al. Distribution of Candida species isolated from blood cultures in hospitals in Osaka, Japan [ J ]. J Infect Chemother,2014,20 (9) :558.