氟比洛芬酯注射液联合芬太尼静脉输注用于术后镇痛的临床观察

Clinical observation of Flurbiprofen Axetil Injection combined with intravenous Fentanyl in the postoperative analgesia

目的:观察氟比洛芬酯注射液联合芬太尼静脉输注用于术后镇痛的效果。方法:将100例ASAⅠ～Ⅱ级患者随机分成两组,A组(对照组)术后持续静脉输注芬太尼15μg/h;B组(实验组)术前15 min静脉推注氟比洛芬酯注射液1 mg/kg,术后持续静脉输注芬太尼15μg/h。观察并记录患者术后1、3、6、12、18、24 h视觉模糊(VAS)评分,镇痛满意度,追加补救镇痛药的例数及不良反应的发生例数。结果:术后1、3、6、12 h B组镇痛VAS评分低于A组(P<0.01或P<0.05),18 h后两组镇痛评分差异无统计学意义。A组优良率为64%,B组为96%,两组镇痛优良率比较差异有统计学意义(P<0.05),在术后1～12 h内A组有18例需肌注哌替啶来缓解疼痛,B组仅2例,两组比较差异有统计学意义(P<0.05)。结论:术前15 min静脉输注氟比洛芬酯注射液1 mg/kg增强了小剂量芬太尼的镇痛效果,同时减少了阿片类药物的用量,降低了不良反应发生率。

Objective： To observe the effect of Flurbiprofen Axetil Injection combined with intravenous Fentanyl in the postoperative analgesia. Methods： 100 patients in ASA I - II level were randomly divided into two groups, the control group （group A） was given persistent intravenous Fentanyl, 15 μg/h; the experimental group （group B） was given intravenous Flurbiprofen Axetil Injection of 1 mg/kg at 15 minutes before the operation and persistent intravenous Fentanyl 15 μg/h af- ter the operation. The postoperative 1, 3, 6, 12, 18 and 24 h visual analogue scale （VAS） scores and analgesic satisfaction, the number of additional remedy analgesics and adverse reaction were observed and recorded. Results： The VAS analgesia score of group B at l, 3, 6 and 12 h after operation were lower than group A （P〈0.01 or P〈0.05）. At 18 h, the difference of the analgesia score between the two groups was not significant. The good rate of group A was 64%, which of group B was 96%, there was significant difference of analgesia good rate between the two groups （P〈0.05）. During 1-12 h after opera- tion, there were 18 patients in group A and 2 cases in group B needing to muscle note Pethidine to ease pain, with signifi- cant difference between the two groups （P〈0.05）. Conclusion： The treatment of intravenous Flurbiprofen Axetil Injection of 1 mg/kg at 15 minutes before the operation can enhance the analgesic effect of the small dose of Fentanyl, reduce the dosage of Opioids at the same time and lower the adverse reaction rate.