原发性高血压肾病患者血清C-反应蛋白和尿微量蛋白水平检测的临床意义

Clinical significance of detection of serum CRP and urine microprotein levels in patients with primary hypertension nephropathy

目的:探讨原发性高血压肾病患者血清C-反应蛋白(CRP)和尿微量蛋白水平的变化及临床意义。方法:应用免疫比浊法对86例原发性高血压患者(正常蛋白尿组27例、微量蛋白尿组29例、大量蛋白尿组30例)血清CRP和尿微量蛋白水平进行检测,并与38例健康受试者(正常对照组)进行对比分析。结果:微量蛋白尿组及大量蛋白尿组患者血清CRP水平[(5.18±0.59)、(9.87±1.02)mg/L)]、尿IgG[(20.02±1.98)、(36.17±4.01)mg/L]、Alb[(70.46±7.12)、(260.31±24.08)mg/L]、TRF[(4.48±0.51)、(5.61±0.58)mg/L)]、α1-MG[(29.87±2.82)、(55.64±5.70)mg/L]、β2-MG[(2.57±0.31)、(5.28±0.62)mg/L]等各项微量蛋白指标水平显著高于正常对照组与正常蛋白尿组,差异均有统计学意义(均P<0.05);高血压肾病患者尿中白蛋白排泄率(UAER)与血清CRP及各项尿IgG、Alb、TRF、α1-MG、β2-MG等各项微量蛋白指标水平呈正相关(r=0.62、0.58、0.54、0.63、0.72、0.49,均P<0.05)。结论:检测原发性高血压肾病患者血清CRP和尿微量蛋白水平对观察其病情变化具有重要的临床价值。

Objective： To explore the clinical significance of detection of serum CRP and urine microprotein levels in the patients with primary hypertension nephropathy. Methods： Serum CRP and urine micropmtein levels were detected with immunoturbidimetry in 86 patients （27 cases of the normal albuminuria group, 29 cases of the microalbuminuria group and 30 cases of the maeroalbuminuria group） with primary hypertension nephropathy, and compared with those of 38 healthy sub- jects （the control group）. Results： Serum CRP [（5.18±0.59）, （9.87±1.02）mg/L）], urine IgG [（20.02±1.98）, （36.17±4.01）mg/L], Alb [（70.46±7.12）, （260.31±24.08）mg/L], TRF [（4.48±0.51）, （5.61＋0.58）mg/L）], α1-MG [（29.87±2.82）, （55.64±5.70）mg/L], β2-MG [（2.57±0.31）, （5.28±0.62）mg/L] in the microalbuminuria group and large number buminuria group were significantly higher than those in the control group and the normal albuminuria group （all P〈0.05）. UAER was positively correlated with serum CRP and urine microprotein levels of IgG, Alb, TRF, α-MG and 132-MG （r=-0.62, 0.58, 0.54, 0.63, 0.72, 0.49 respectively, all P〈0.05）. Conclusion： The detection of serum CRP and urine microprotein are all sensitive in observing the change of diseases in oatients with orimarv hvpertension neohropathv.