慢性乙肝病毒携带者血清HBV DNA载量与胶原合成能力的相关性研究

Correlation study of HBV DNA loads and collagen synthetic ability in chronic hepatitis B virus carriers

目的探讨不同类型乙肝病毒(HBV)携带者在肝纤维化进展程度上的差异。方法选取已进行肝组织活检的慢性HBV携带者164例,以1×105拷贝/mL为界分为高载量组和低载量组,3H-脯氨酸掺入法检测二者HSC总胶原和Ⅰ型胶原合成能力的区别。结果不同纤维化分期与HBV DNA载量之间无显著性差异(P>0.05);高载量组与低载量组均有较强的总胶原合成能力,两者之间无显著性差异(P>0.05);高载量组与低载量组均有较强的Ⅰ型胶原合成能力,两者之间无显著性差异(P>0.05)。结论肝纤维化进展及胶原合成能力与HBV载量不具有相关性,慢性HBV携带者亦应行抗纤维化治疗以减慢肝脏纤维化进程。

Objective It is to approach the difference of different types of chronic hepatitis B virus（HBV） carriers at progression degree of hepatic fibrosis.Methods One hundred and sixty-four chronic HBV carriers executed hepatic tissue biopsy were chosen and randomly divided into high load group and lower load group with the delimitation of 1×105 copy/mL.The differences of synthesis ability of HSC total collagen and type Ⅰ collagen in the two groups were detected with 3H-proline incorporate method.Results The difference between different fibrosis staging and HBV DNA loads was not significant（P0.05）.High load group and lower load group both had stronger synthesis abilities of total collagen and type Ⅰ collagen and the differences were not significant（both P0.05）.Conclusion It is not correlation of hepatic fibrosis progression and collagen synthesis ability with HBV DNA loads.Chronic HBV carriers should receive antifibrotic therapy to slow down the process of liver fibrosis.