重症监护病房患者检测降钙素原和C反应蛋白的临床意义

Clinical significance of detection of procalcitonin and C-reactive protein in intensive care unit

目的探讨检测降钙素原(PCT)和C反应蛋白(CRP)对重症监护病房(ICU)患者细菌感染的临床意义。方法选取2008年2月至2010年8月在ICU病房住院的67例患者,空腹抽取所有患者静脉血3ml,3000r/min离心分离血清备用,检测所有标本的血清PCT和CRP的浓度水平,结合细菌培养结果和临床诊断,分析血清降钙素原(PCT)和C反应蛋白(CRP)的浓度水平在ICU患者细菌感染的临床意义。结果一般感染组与严重脓毒症组血清PCT和CRP浓度比较差异均具有统计学意义,但PCT的差异性高于CRP。t值分别为3.3475、2.9291,P<0.01。结论当患者细菌感染时,虽然PCT和CRP均具有诊断意义,但PCT比CRP具有更高的特异性和灵敏性,所以PCT有更高的临床应用价值。

Objective To discuss the clinical significance of examination ofprocalcitonin （PCT） and C-reactive.protein （CRP） in intensive care unit （ICU）. Methods Sixty-seven patients in intensive care unit （ICU） from Febmary, 2008 to August, 2010 were selected for this study. The venous blood （3 ml） on empty stomach was collected, centrifuged （3 000 r/min）, and separated for further use. The levels of PCT and CRP were detected and analyzed for their clinical significance in bacterial infection. Results The levels of PCT and CRP showed significant difference between the general infection group and serious infection group, but difference in PCT was more pronounced than that in CRP. The T values were 3.347 5 and 2.929 1, with P〈0.01. Conclusion Levels of PCT and CRP both have great significance in the diagnosis of bacterial infection, but PCT is preferred, with higher specificity and sensitivity.