血小板和超敏C反应蛋白检测对川崎病的诊断价值

Value of platelet and high sensitive C-reactive protein in the diognosis of Kawasaki disease

目的评估血小板(PLT)和超敏C反应蛋白(hs-CRP)在川崎病(KD)患儿中的变化并探讨其在KD患儿早期诊断的临床意义。方法检测56例KD患儿(KD组)治疗前(发热1周内)及予丙种球蛋白规范治疗2周后的PLT及hsCRP,与57例症状相似的非KD患儿(对照组)对比,进而分析PLT及hs-CRP与KD的关系。结果发热一周内两组PLT的t值为4.432(P<0.01),CRP的Z值为-1.987(P<0.05),疾病早期KD组PLT及hs-CRP显著高于与KD,差异有统计学意义(P<0.05)。予丙种球蛋白治疗两周后两组PLT的y值为0.411(P>0.05),CRP的Z值为-0.236,差异无统计学意义(P>0.05)。结论 PLT和hs-CRP的早期升高水平与KD密切相关,可以作为早期诊断川崎病的因子之一。

Objective To investigate the changes of platelet （PLT） and high sensitive C-reactive protein （hs-CRP） in children with Kawasaki disease, and to explore its clinical significance in the early diagnosis of Kawasaki disease. Methods Fifty-six children with Kawasaki disease and 57 children having similar syndromes without Kawasaki dis- ease were selected as the study group and the control group. Levels of PLT and hs-CRP within seven days after fever and two weeks after treatment by immunoglobulin were detected. The results were compared between the two groups. Results Within seven days after fever, the t value of the levels of PLT between the two groups was 4.432 （P〈0.01）, and the Z value of levels of hs-CRP between the two groups was -1.987 （P〈0.05）. Both the levels of PLT and hs-CRP in the study group were significantly higher than that in the control group within seven days after fever （P〈0.05）. Two weeks after treatment by immunoglobulin, the t value of the levels of PLT between the two groups was 0.411 （P〉0.05）, and the Z value of levels of hs-CRP between the two groups was -0.236 （P 〉0.05）. There was no statistically significant difference be- tween the study group and the control group （P〉0.05）. Conclusion The levels of PLT and hs-CRP are correlated with Kawasaki disease closely, and could be used as effective items for early diagnosis of Kawasaki disease.