尿视黄醇结合蛋白在肾脏病中的检测及评价

Clinical value of detection of urinary retinol-binding protein for renal disease

目的探讨尿液视黄醇结合蛋白(UrRBP)作为肾脏疾病患者肾小管功能损害的筛选指标及其在肾脏病诊断中的价值。方法应用免疫透射比浊法对对照组和不同肾脏病组进行UrRBP测定。结果不同肾脏病组的UrRBP值:肾病综合征组为(11.12±7.198)mg/L,肾小球肾炎组为(3.394±2.806)mg/L,糖尿病肾病组为(6.440±4.928)mg/L,狼疮性肾炎组为(9.982±6.818)mg/L,与对照组的(0.2915±0.061)mg/L比较,各肾脏病组与对照组差异有统计学意义(P<0.01)。结论 UrRBP测定能放映出肾小管的损害程度,是检测肾小管功能损害的敏感指标。

Objective To investigate urinary retinol-binding protein （UrRBP） as the filter indicators for tubular function in patients with renal disease and its value in the diagnosis of renal disease. Methods Applying immunoturbidimetric assay, levels of UrRBP were detected in the control group and four groups of patients with different kinds of renal disease （nephritic syndrome group, glomerular nephritis group, diabetic nephropathy group, and lupus nephritis group）. Results Levels of UrRBP for patients with nephritic syndrome, glomerular nephritis, diabetic nephopathy and lupus nephritis were （11.12±7.198） mg/L, （3.394± 2.806） rag/L, （6.440±4.928） mg/L and （9.982±6.818） mg/L, which showed statistically significant difference with that in the control group [（0.2915±0.061） mg/L]. Conclusion Level of UrRBP can reflect the degree of tubular damage, serving as a sensitive index for evaluating renal disease.