124例系统性红斑狼疮瘀热毒相关指标分析

124 cases of systemic lupus erythematosus drug-related clinical cases stasis heat index analysis

目的:从临床研究探讨瘀热毒在系统性红斑狼疮发病中的重要作用。方法:对124例SLE临床病例瘀热毒相关症状、体征、实验室指标进行统计,并作相关性分析。结果:通过文献研究及临床研究,我们认为与瘀、热、毒相关的症状、体征有:面部皮疹/红斑、口腔溃疡、皮肤血管炎/血栓、甲周红斑/冻疮、雷诺现象、紫癜、发热、腹痛、烦躁、癫痫、肝/脾大、淋巴结肿等。实验室与瘀相关的指标有:血小板、凝血功能、D2聚体、血脂、抗心磷脂抗体等。与毒相关度的指标有:自身特异性相关抗体免疫指标,如IGG、C3、抗ENA等8项。与热相关的指标:如血沉、C反应蛋白等。药物治疗中,活血化瘀药、抗血小板/抗凝药、激素、抗生素是主要用药。结论:瘀热毒为系统性红斑狼疮的主要病理因素,热毒炽盛,深入营血,血络瘀阻,往往是系统性红斑狼疮活的基本病机,在本病的发病中起到了极其重要的作用,而瘀贯穿病程始终。

Objective： Clinical studies of toxic heat stasis in the pathogenesis of systemic lupus erythematosus important role.Methods： The clinical cases of 124 patients with SLE stasis toxic heat-related symptoms,signs,laboratory indicators,statistics,and for correlation analysis.Results： The literature and clinical studies,we believe that with the stasis,heat,drugs-related symptoms and signs include： facial rash / erythema,oral ulcers,skin vasculitis / thrombosis,a week of erythema / frostbite,Raynaud＇s phenomenon,purpura,fever,abdominal pain,irritability,seizures,liver / spleen large,swollen lymph nodes and so on.Laboratory and stasis-related indicators are： platelets,coagulation,D2 polymers,lipids,anti-cardiolipin antibodies.Correlation with drug indicators are： self-specific antibody-related indicators,such as the IGG,C3,anti-ENA,etc.8.Heat-related indicators： such as erythrocyte sedimentation rate,C-reactive protein.Drug treatment,the blood circulation drugs,antiplatelet / anticoagulant drugs,hormones,antibiotics are the main drug.Conclusion： stasis heat toxin as the major pathological factors of systemic lupus erythematosus,toxic heat flaming,in-depth business of blood,blood stasis network,systemic lupus erythematosus is often the basic pathogenesis of living in the pathogenesis of this disease has played an extremely important role,and stasis throughout the course of the disease has always been.