摘要
目的探讨胃肠道间质瘤(GIST)中CD117、CD34、SMA及S-100的表达以及四个免疫组化标志物的相关性。方法对24例手术切除的GIST复习其临床特点及病理形态,用免疫组化方法检测GIST中CD117、CD34、SMA及S-100的表达。结果免疫组化结果:CD117阳性率79.14%,CD34阳性率79.14%,SMA阳性率54.17%,S-100阳性率12.50%,统计分析结果:CD117与CD34呈正相关性(r=0.495,P=0.014),CD117与S-100负相关(r=-0.427,P=0.038),CD117、CD34、SMA、S-100在良性组、潜在恶性及恶性组比较差异均无统计学意义(P>0.05)。结论结合GIST的临床病理特点,免疫组化CD117和CD34阳性及其相关性是确诊GIST最可靠和最有价值的依据,CD117、CD34、SMA及S-100作为GIST良恶性鉴别参考指标意义不大。
Objective To study the immunohistochemical features of gastrointestinal stromal tumors（GIST）.Methods The expressions of CD117、CD34、SMA、S-100 of the GIST were studied by immunohistochemistry method（EliVision plus）.Results By immunohistochemical staining detection,the positive expression rates of CD117、CD34、SMA and S-100 in GIST cases were 79.17%,79.17%,54.17% and 12.5%.Conclusion GIST can be identified by the combining applying of CD117、CD34 and SMA、S-100 through the immunohistochemistry method.
出处
《广州医药》
2011年第6期14-17,共4页
Guangzhou Medical Journal
关键词
胃肠间质瘤
病理学
免疫组化
Gastrointestinal stromal tumors
Clinical pathology
Immunohistochemistry
