益精稳压方早期干预对SHR血压、ET-1及TM水平的影响

Effect of Early Intervention with Yijingwenya Formula on Blood Pressure,Endothelin-1 and Thrombo Modulin in SHR

目的:观察早期应用中药益精稳压方干预对大鼠高血压发生的预防抑制作用以及可能的作用机制。方法:取自发性高血压大鼠(SHR)32只,随机分为模型组、中药干预低、中、高剂量组,各8只,WKY大鼠8只为正常对照组。中药干预高、中、低剂量组分别予益精稳压中药3.16、1.58、0.79g/mL灌胃,正常组与模型组予等量蒸馏水灌胃。观察各组治疗前、中、后血压、ET-1及TM水平。结果:与正常组比较,模型组及中药干预组大鼠血压、血ET-1及血TM水平明显上升,差异有统计学意义(P<0.01);与模型组比较,中药中、高剂量组血压、血ET-1及血TM水平下降,差异有统计学意义(P<0.05)。同组大鼠治疗前后比较,中药中、高剂量组大鼠血压升高进展延缓,ET-1及血TM水平升高幅度下降。结论:益精稳压方早期干预可延缓自发性高血压大鼠高血压进展,其机制可能与降低ET-1及TM水平有关。

Objective： To investigate the effect of Yijingwenya formula on blood pressure,endothelin-1（ET-1）,and thrombo modulin（TM） in the early stage of spontaneous hypertension rats（SHR）.Methods： A total of 32 SHR were randomized into a model group and low-dose,medium dose,and high-dose of Yijingwenya formula groups,8 in each.Another 8 WKY rats served as controls.Three doses of Yijingwenya formula were 0.79,1.58,and 3.16 g/mL in order intragastrically given to the corresponding Chinese medical groups,while equivalent volume of distilled water was administered in the same way to the model and control groups.Blood pressure and levels of ET-1 and TM were measured before,during and after intervention.Results： Compared to the control group,other groups had elevated blood pressure,serum ET-1 and TM（P0.01）;compared with the model group,blood pressure and the levels of the 2 proteins were lower in all Chinese medical groups（P0.05）.Within a group,a postponed elevation of blood pressure and a reduction of increase of ET-1 and TM were noted in the high-and medium-dose of Yijingwenya formula groups.Conclusion： Early intervention with Yijingwenya formula can delay the development of blood pressure by reducing the levels of ET-1 and TM.