摘要
透明质酸(HA)与甲基丙烯酸缩水甘油酯(GMA)接枝形成GMAHA衍生物,在60Co-γ射线辐照环境下,GMAHA衍生物在水溶液中形成交联HA凝胶。流变学检测数据显示,交联HA凝胶的存储模量G'显著高于损耗模量G″,且对剪切频率的依赖性不明显,表现出了高弹性凝胶特征;交联HA凝胶在水中稳定性较好,可吸收自身质量20~50倍的水分,在分子量一定的情况下,交联HA凝胶的吸水量随着GMAHA质量分数和一定范围内辐照剂量的增加而减小;咔唑显色法检测的糖醛酸结果显示,交联HA凝胶的抗氧化性和耐酶解性较交联前有很大提高;在制备条件一定的情况下,环境pH值、温度是影响该交联HA凝胶抗氧化性、耐酶解性的主要因素。
Glycidyl methacrylate(GMA) has been grafted onto hyaluronic acid(HA) to form GMAHA conjugates.After treating the solution of GMAHA derivatives with 60Co-γ irradiation,a cross-linked HA gel was obtained.The value of the storage modulus(G′) of the HA gel was larger than the value of the loss modulus(G″) and the slopes approached zero.The cross-linked HA gel can be characterized as a strong hydrogel.The HA gel absorbed 20-50 times its own weight of water.For a fixed molecular weight of HA,the water uptake capability of the cross-linked HA gel decreased as the concentration of GMAHA and γ-ray dosage increased within a certain range.The cross-linked HA gel is a degradable material.The antioxidative and anti-enzymolysis capabilities of the cross-linked HA gel were considerably superior to those of HA itself.When the preparation conditions were varied,it was found that the pH and the ambient temperature were the main factors influencing the anti-oxidative and anti-enzymolysis capabilities of the resulting cross-linked HA gel.
出处
《北京化工大学学报(自然科学版)》
CAS
CSCD
北大核心
2011年第6期49-53,共5页
Journal of Beijing University of Chemical Technology(Natural Science Edition)
关键词
交联
流变学分析
吸水性能
抗氧化性
耐酶解性
cross-linked
rheological analysis
water uptake capability
anti-oxidative capability
anti-enzymolysis capability