序贯疗法与7d三联疗法治疗幽门螺杆菌的疗效比较

Comparative Study Between Sequential Therapy and 7-day Triple Therapy in Helicobacter Pylori Infection Treatment

目的:比较序贯疗法与7d三联疗法治疗幽门螺杆菌的疗效。方法:92例HP阳性病例,随机分为两组:治疗组:42例前5d予质子泵抑制剂(proton pump inhibitor,PPI)和阿莫西林,后5d予PPI、克拉霉素和替硝唑。对照组:50例予PPI、阿莫西林和克拉霉素,疗程7d。结果:序贯疗法HP根除率为97.62%,7d三联疗法HP根除率为36%。结论:序贯疗法与7d三联疗法对本地区的根除率有显著差异。

Objective：To assess the efficacy of sequential regimen compared with conventional 7-day triple therapies.Methods：92 Helicobacter pylori（H.pylori） infected patients were enrolled.All patients were randomized either to receive 10-day sequential therapy Group（42cases）,proton pump inhibitor（PPI） plus amoxicillin for the first 5 days,followed by PPI,clarithromycin and tinidazole twice daily for the remaining 5 days or to standard 7-day therapy Group（50cases）,PPI,clarithromycin and amoxicillin twice daily.Results：H.pylori eradication was achieved in 41（97.62%） of 42 individuals in Sequential regimen,18（36%） of 50 in 7-day triple therapies.Conclusion：The sequential regimen is significantly more effective than 7-day triple therapies in this area.