广州地区中老年人群白细胞介素-6和纤溶酶原抑制物1水平分析

The analysis of serum interleukin 6 and fibrinolytic enzyme inhibition content 1 in the middle-aged and elderly in Guangzhou region

目的调查广州地区中老年人群的血清白细胞介素-6(IL-6)、纤溶酶原抑制物1(PAI-1)水平。分析广州地区中老年人群血清IL-6、PAI-1水平影响因素。评估中老年人群血清IL-6、PAI-1水平同糖代谢紊乱和心脑血管危险因素上升的相关性。方法从广州生物库队列研究中第3阶段(2006年11月至2007年9月)收集的10 027例研究对象中随机选出,对其中1 500例受检者用酶联免疫吸附试验同时测定血清IL-6和PAI-1水平。男740例,平均年龄(61.9±6.9)岁;女760例,平均年龄(56.0±5.2)岁。结果广州市1 500例受检者的血清IL-6水平男性为(12.29±2.12)pg/mL,女性为(7.37±2.06)pg/mL;PAI-1水平男、女性分别为(96.73±3.66)ng/mL和(87.48±3.21)ng/mL。男女血清IL-6水平均随腰围、体质量指数、空腹血糖、低密度脂蛋白胆固醇(LDL-C)、总胆固醇和三酰甘油(TG)增加而显著升高,差异有统计学意义(P<0.01),同时还随男性的空腹血糖及高密度脂蛋白胆固醇降低而显著升高,差异有统计学意义(P<0.05)。男、女性血清IL-6和PAI-1水平在血清葡萄糖(GLU)升高组明显高于血清GLU正常组。血清PAI水平在血清血脂升高组明显高于血清血脂正常组。血清IL-6在血清胰岛素升高组明显高于血清胰岛素正常组。结论广州地区相对健康的中老年男性和女性PAI水平同年龄增加呈显著相关。广州地区相对健康的中老年人男性和女性血清IL-6、PAI水平在血糖升高组中明显高于血糖正常组,同血糖浓度呈正相关。广州地区相对健康的中老年人男性和女性血清IL-6水平同胰岛素浓度呈正相关。血清IL-6水平与肥胖和吸烟呈正相关。广州地区相对健康的中老年人血中PAI-1水平与血糖、血TG及LDL-C呈正相关。中老年人群血清IL-6、PAI-1水平同糖、脂代谢紊乱,心脑血管危险因素上升有明显的相关性。

Objective To investigate the serum interleukin 6（IL-6） and fibrinolytic enzyme inhibition content 1（PAI-1） level in middle-aged and elderly in Guangzhou region,and to assess the serum IL-6 level,fibrinolytic enzyme inhibition PAI-1 level with glucose metabolic disorder,and cerebrovascular risk factor rising correlation of the middle-aged and elderly.Methods 10 027 samples were ramdomly chosen from guangzhou biobank cohort study in the 3rd stage（Nov.2006 to Sep.2007）,1 500 of which underwent conscription examination with ELISA and the serum IL-6,fibrinolytic enzyme inhibition content level were determined simultaneously.There were 740 men,with（61.9±6.9） years of age on average.There were 760 female,with average age of（56.0 ±5.2） years old.Results The male and female serum IL-6 levels of the 1 500 samples were（7.37±2.06） pg/mL and（12.29±2.12） pg/mL,respectively.The male and female fibrinolytic enzyme inhibition content levels were respectively（96.73± 3.66）ng/mL and（87.48 ± 3.21）ng/mL.Serum IL-6 level in both sexes increased with waist circumference,BMI,SBP and LDL-C,CHO and TG increased significantly（P0.01） and increased with the decrease of male fast blood sugar rised and HDL-C significantly（P0.05）.Female serum IL-6 and fibrinolytic enzyme inhibition content were obviously higher than the elevated GLU of the normal group.The serum fibrinolytic enzyme inhibition in serum lipid content level of serum lipid increased significantly than the normal group.Serum IL-6 in serum insulin rose significantly than normal serum levels of the insulin group.Conclusion The PAI levels of Guangzhou area relatively healthy elder men and women have the positive relationship to the increase of age.The serum IL-6 level,fibrinolytic enzyme inhibition in blood sugar level of the things in the group of high blood sugar in Guangzhou healthy elder men and women are obviously higher than the normal group.It is positively correlated to blood sugar concentration.The serum IL-6 level in the healthy elder men and women in Guangzhou area is positively correlated to the insulin concentrations.Serum IL-6 level was positively associated with obesity and smoking.The PAI-1 levels in the blood and blood sugar,blood triglycerides,low density lipoprotein cholesterol in the healthy elderly in Guangzhou area were positively correlated.The risk factors of serum IL-6 level,fibrinolytic enzyme inhibition PAI-1 level of middle-aged and the elder people are correlated with sugar,fat supersession chaos,cardiovascular.