帕金森病患者血尿酸水平的研究

Clinic study on uric acid in patients with Parkinson′s disease

目的探讨帕金森病(PD)患者血尿酸水平与临床运动和非运动症状的关系。方法将101例原发性PD患者分为PD组、男性PD和女性PD组,检测血尿酸水平,同时应用统一PD评分量表Ⅲ、PD非运动症状30问卷量表、蒙特利尔认知评估量表、汉密尔顿抑郁量表进行评估,并与血尿酸水平比较。同时收集与PD组年龄、性别相匹配的健康体检者作为对照组。结果 PD组的尿酸水平为(315.4±71.83)μmol/L,明显低于对照组[(332.06±83.36)μmol/L],差异有统计学意义(P<0.05)。PD患者的血尿酸水平和性别相关,男性(336.01±74.72)μmol/L,高于女性[(293.25±108.84)μmol/L],差异有统计学意义(P<0.05);男性PD患者血尿酸和临床分型相关(r=0.342,P<0.05);PD组(r=-0.255,P<0.05)和女性PD患者(r=-0.32,P<0.05)血尿酸和非运动症状亚组中的心境/认知相关。结论 PD患者血尿酸水平降低很可能为PD的危险因素之一,血尿酸水平和一些运动和非运动症状具有一定的相关性,值得进一步研究。

Objective To explore the relation between uric acid in patients with Parkinson′s disease（PD） and motor symptoms and non-motor symptoms.Methods 101 patients with PD were classified as PD,male PD and female PD groups and their serum uric acid contents were examined,and 100 healthy persons whose age,sex matched the patients were enrolled as the controls.We used unified Parkinson diseases rating scale part Ⅲ,the PD NMS Questionnaire and Montreal Cognitive Assessment and Hamilton Depression Rating Scale to assess the patients.Results The serum uric acid level in PD（315.4±71.83 μmol/L） was lower than that in the controls [（332.06±83.36）μmol/L,P0.05].The serum uric acid level in PD was gender related and male PD patients（336.01±74.72） μmol/L had a higher serum uric acid level than female patients[（293.25±108.84）μmol/L,P0.05].In male PD patients,the serum uric acid level was correlated with clinical types（r=0.342,P0.05）.In PD patients（r=-0.255,P0.05）and female PD patients（r=-0.32,P0.05）,the serum uric acid level was correlated with mood and recognition symptoms in NMS Quest.Conclusion Lower serum uric acid level is probable a risk facor in PD.There are some correlations between serum uric acid level and motor symptoms and non-motor symptoms,which needs further investigation.