血清总同型半胱氨酸 叶酸 维生素B_(12)水平与认知功能障碍的相关性

The relationship between serum total homocysteine,folate,vitamin B_(12) levels and cognitive impairment

目的研究分析血清总同型半胱氨酸(tHcy)、叶酸(FA)、维生素B12(VitB12)水平与认知功能障碍的相关性。方法选择阿尔茨海默病患者48例、轻度认知功能障碍患者57例、健康对照者60例,以比色法测定血清tHcy水平;化学发光法测定FA、VitB12水平。结果阿尔茨海默病和轻度认知功能障碍患者tHcy水平显著高于健康对照者,差异有统计学意义(P<0.01),FA、VitB12水平与健康对照者相比差异有统计学意义(P<0.05)。结论阿尔茨海默病和轻度认知功能障碍患者血清tHcy水平显著增高,tHcy、FA、VitB12可能与认知功能障碍的发病机制有关。

Objective To study the relationship between serum total homocysteine（tHcy）,folic acid（FA）,vitamin B12 （VitB12） level and cognitive impairment. Methods The serum tHcy level was determined by colorimetry and the serum FA, Vit B12 levels were determined by chemiluminescence in 48 cases of Alzheimer＇s disease（AD）, 57 cases of mild cognitive impairment and 60 cases of health controls. Results The tHcy levels were significantly higher than those of the health controls（P〈0.01） in the AD or MCI;As for FA,VitB12 levels, there was significant difference（P〈0.05） between the AD or MCI and the health controls. Conclusion The serum tHcy level was significantly high in the AD or MCI,the tHcy,FA,VitB12 may be related with cognitive impairment.