三维适形放射治疗食管癌放疗后复发的研究

Study of 3 dimensional conformal radiation therapy for local recurrence after radical radiotherapy of esophageal carcinoma

目的探讨三维适形放射治疗在根治性食管癌放疗后复发的治疗效果。方法 60例食管癌常规根治性放疗后复发病例行三维适形放射治疗,评价近期疗效、生存率及急性放射反应。结果 60例患者均顺利完成放射治疗,肿瘤的完全缓解率为58.33%(35/60),部分缓解率为20.00%(12/60),无变化率为13.33%(8/60),恶化率为8.33%(5/60);6个月生存率为65.00%(39/60),1年生存率为51.67%(31/60),2年生存率为33.33%(20/60),3年生存率为16.67%(10/60)。急性放疗反应均可以耐受。结论三维适形放射治疗可以作为食管癌根治性放疗后局部复发患者的一种有效治疗手段,且患者的耐受性好。

Objective To evaluate the effect of 3 dimensional conformal radiation therapy for recurrence esophageal carcinoma after radical radiotherapy.Methods 60 esophageal carcinoma patients with local recurrence after their initial radiotherapy received retreatment with stereotactic radiotherapy.The acuate side effect,survival rates and immediate response were evaluated.Results All 60 patients completed there seconed course radiotherapy.The overall response rate was 78.2% with CR in 35 patients（58.3%）,PR in 12 patients（20%）,SD in 8 patients（13.3%） and PD in 5 patients（8.3%）.The survival rate of patients within 6 months was 65%（39/60）,and for 1,2 and 3 year were 31（51.6%）,33.3%（20/60）,16.7%（10/60）,respectively.Conclusion 3 dimensional conformal radiation therapy is an alternative effective method for the in-patients with recurrence esophageal carcinoma after radical radiotherapy.