摘要
目的采用受试者工作特征曲线(ROC)分析法评价血清鳞状细胞癌抗原(SCC-Ag)水平检测在宫颈癌诊断中的临床应用价值。方法收集88例宫颈癌患者和103例健康体检者血样和资料,采用酶联免疫吸附试验测定所有对象血清SCC-Ag水平。采用MedCalc软件绘制ROC,对血清SCC-Ag诊断宫颈癌的准确性进行评价。结果与健康对照组相比较,宫颈癌组血清SCC-Ag水平均有明显升高,差异有统计学意义(P<0.05);ROC显示,血清SCC-Ag诊断宫颈癌的灵敏度为78.4%,AUC特异性为80.5%,ROC下面积为0.80。结论血清SCC-Ag水平与宫颈癌的发生密切相关,血清SCC-Ag水平检测在宫颈癌的诊断中有较好的临床应用价值。
Objective To evaluate the clinical diagnostic value of serum squamous cell carcinoma antigen（SCC-Ag） by ROC curve in diagnosis of cervical cancer.Methods The serum level of squamous cell carcinoma antigen（SCC-Ag） in 88 cervical carcinoma patients（experimental group） and 103 healthy individuals（control group） were detected by Enzyme-linked immunosorbent assay.A ROC curve was used to evaluate the accuracy of serum SCC-Ag in the diagnosis of cervical cancer.Results Serum SCC-Ag levels in the experimental group were significantly higher than that in the control group（P0.05）.The sensitivity,specificity of serum SCC-Ag diagnosing cervical cancer were 78.4% and 80.5%,respectively.The area under the ROC curve was 0.80.Conclusion It is suggested that serum SCC-Ag levels is closely related to cervical cancer.The serum SCC-Ag level is a useful diagnostic marker in cervical cancer.
出处
《检验医学与临床》
CAS
2011年第22期2747-2748,共2页
Laboratory Medicine and Clinic
