奥氮平与利培酮治疗脑血管疾病所致精神障碍的对照研究

A control study on the treatment of olanzapine and risperidone on mental disorders caused by the cerebrovascular disease

目的探讨奥氮平治疗脑血管疾病所致精神障碍的疗效和安全性。方法将52例脑血管疾病所致精神障碍患者随机分为两组,奥氮平组26例,利培酮组26例,分别给予两种药物治疗4周。采用阳性和阴性症状量表评定临床疗效,采用不良反应量表及有关实验室检查评定不良反应。结果治疗4周后两种药物的疗效近似,差异无统计学意义(P>0.05)。结论奥氮平治疗老年痴呆精神行为障碍疗效与利培酮相当,但起效时间比较快、不良反应较利培酮少,更适用于老年患者。

Objective To explore the efficacy and safety of the treatment of olanzapine,which is used to treat the mental disorders that caused by cerebrovascular disease.Methods 52 mental disorders caused by cerebrovascular disease patients were divided into olanzapine group and risperidone group randomly,with 26 patients in each group.All patients received 4 weeks′ treatment.The clinical curative effect was assessed by the positive symptoms and negative symptoms scale（PANSS）,and the adverse reactions were assessed by adverse reactions scale（treatment） and relevant laboratory evaluation.Results The treatment effect of the two drugs were approximated after 4 weeks′ treatment（P0.05）.In Risperidone group,the incidence of adverse reaction such as insomnia,muscular rigidity and tremor could not sit still and the endocrine change was obviously higher than that of the olanzapine group（P0.05）.Conclusion The treatment effects at spirit behavior dysfunction of dementia patients are similar between olanzapine and risperdal,but the work time is faster,and the adverse reactions is less in the olanzapine group than that in the risperdal group.Olanzapine was more applicable for elderly patients.