肝细胞生长因子在子宫内膜异位症患者血清中的表达及临床意义

Expression and clinical significance of hepatocyt growth factor in endometriosis

目的探讨肝细胞生长因子(HGF)在子宫内膜异位症(Ems)发病过程中的作用及临床应用价值。方法采用ELISA法检测Ems组、正常组和对照组患者血清HGF的浓度。结果 EMs组血清HGF含量高于正常组、对照组(P均<0.05),Ⅲ～Ⅳ期(88%)Ems患者的HGF高于Ⅰ～Ⅱ期(62%)(P<0.05)。EMs组中单项检测HGF、CA125阳性率分别为71%和60%。HGF和CA125联合检测如以两项之一阳性为阳性判断标准,EMs组阳性率为84%,其中Ⅲ～Ⅳ期患者阳性率高达100%。单项检测血清HGF对Ems诊断的敏感性及特异性(71%、92%)均高于单项检测血清CA125(60%、84%),但两者比较无统计学意义(P>0.05)。HGF和CA125联合检测如以两项均阳性为阳性判断标准,敏感性下降为43%,但特异性为99%,阳性预测值高达100%。结论 HGF可能参与Ems的发病过程,检测血清HGF对Ems的诊断有重要临床参考价值。

Objective To investigate the role of hepatocyt growth factor （HGF） in the pathogenesis of endometriosis （EMs） and its clinical potential value. Method ELISA method was used to detect the expression of HGF in serum of Ems group, normal group and control group. Results The expression of HGF in EMs group was higher than that in control and normal group （ P 〈 O. 05 ）, and HGF level in tage Ⅲ -Ⅳ EMs patients （88%） was higher than that in stage Ⅰ - Ⅱ （62%） （P 〈0.05）. The positive rate of HGF and CA125 in EMs group were 71% and 60%, respectively. With combined detec- tion of HGF and CA125 （if one of the two was positive, the result was positive）, the positive rate was 84% in EMs group, meanwhile which would be up to 100% in stage Ⅲ-Ⅳ. By single detection of serum HGF on diagnosis of EMs, the sensi- tivity and specificity （71%, 92% ） were higher than single detection of serum CA125 （60%, 84% ）, but there were no significant difference （P 〉 0. 05）. With combined detection of HGF and CA125 （if both of them were positive, the result was positive）, the sensitivity dropped to 43%, whereas the specificity was up to 99%, and the positive predictive value elimed up to 100%. Conclusion The expression of HGF might be involved in the pathogenesis of EMs, and detection of the level of serum HGF on the diaeresis of EMs had imoortant clinical potential value.