乙肝清热解毒颗粒联合干扰素治疗对慢乙肝患者生存质量的影响

Effect of Hepatitis B Qingrejiedu Particles and Interferon Treatment on Quality of in Chronic Hepatitis B Patients

目的:研究乙肝清热解毒颗粒和干扰素对于慢乙肝患者生存质量的影响。方法:选择60例慢乙肝患者,随机分为乙肝清热解毒颗粒联合干扰素的治疗组和单用干扰素的对照组,应用SF-36、CLDQ、慢性肝病中医生存质量量表对两组患者治疗前后分别进行测评,并进行比较。结果:在SF-36量表中,治疗组治疗前后在RP、BP、VT领域有显著差异(P<0.01),对照组治疗前后在RP领域有显著统计学意义(P<0.01),在BP领域治疗组与对照组治疗后比较,有显著性差异(P<0.01)。在CLDQ量表中,治疗组治疗前后在AS、FA、SS领域有显著性差异(P<0.01),对照组治疗前后在AS领域有显著统计学意义(P<0.01),在FA、SS领域治疗组与对照组治疗后比较,有显著统计学意义(P<0.01)。在慢性肝病中医生存质量量表中,治疗组治疗前后在肝经领域有统计学意义(P<0.05),在肝络领域,有显著性差异(P<0.01),对照组在肝经领域差异有统计学意义(P<0.05),治疗组与对照组治疗后比较在肝络领域有显著性差异(P<0.01)。结论:乙肝清热解毒颗粒联合干扰素治疗能提高慢乙肝患者生存质量。

Objective：To evaluate the effect of Hepatitis B Qingrejiedu particles and Interferon treatment on quality of life in chronic hepatitis B patients.Method：60 CHB patients were randomly divided into two groups,one was treated with Hepatitis B Qingrejiedu particles and interferon,the other was underwent the mono therapy of Interferon.SF-36,CLDQ and Chronic Liver Disease Questionnaire of TCM were used to evaluate two groups of patients before and after treatment,then respective comparisons were made between two groups.Result：In SF-36 scale,just as the treatment group,before and after the treatment there were significant differences in RP,BP,VT areas（P〈0.01）;while there was significant difference in RP area before and after treatment of the control group（P〈0.01）;after treatment,the difference between two groups was significant in BP field（P〈0.01）.In CLDQ,concerning the treatment group,there were significant differences before and after the treatment in AS,FA,SS areas（P〈0.01）;regard to the control group,the difference has statistically significant meaning before and after treatment in AS area（P〈0.01）;compared with two groups,there were statistically significances in the FA,SS fields（P〈0.01）.In Chronic Liver Disease Questionnaire of TCM,regard to the treatment group,there was statistically difference in the gangjing field before and after the treatment（P〈0.05）,meanwhile significant difference in ganluo fields（P〈0.01）;with regard to the control group,the difference in the ganjing field statistically（P〈0.05）;comparison of the treatment group and the control group show that the difference was significant in ganluo field（P〈0.01）.Conclusion：The combination therapy of Hepatitis B Qingrejiedu particles and interferon can improve CHB patients＇ quality of life.