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胃肠道间质瘤淋巴结转移的临床及病理特征分析 被引量:5

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摘要 目前,外科手术切除仍是胃肠道间质瘤(gastrointestinalstromal tumor,GIST)的根治性治疗方法,随着受体酪氨酸激酶抑制剂伊马替尼(格列卫)的成功应用,该疾病已成为现代实体肿瘤靶向药物治疗的经典模型。GIST的生物学特征复杂,很难用传统的良、恶性加以区分,目前一般认为该肿瘤均具有潜在恶性倾向,而高度恶性的GIST术后极易复发或转移。GIST最常见的转移方式为腹腔内直接播散及经血行转移至肝脏。不同于胃肠道上皮源性肿瘤的是,GIST很少发生淋巴结转移,国内外文献中偶见报道,其发生率为1%~4%。
出处 《外科理论与实践》 2011年第3期298-300,共3页 Journal of Surgery Concepts & Practice
基金 仁济医院学科建设项目(RJ4101304) 上海交通大学"医工(理)交叉基金"项目(YG2009MS22)
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参考文献14

  • 1Reynoso D, Trent JC. Neoadjuvant and adjuvant imatinib treatment in gastrointestinal stromal tumor: current status and recent developments[J]. Curr Opin Oncol,2010,22(4): 330-335.
  • 2DeMatteo RP, Lewis J J, Leung D, et al. Two hundredgastrointestinal stromal tumors: recurrence patterns and prognostic factors for survival[J]. Ann Surg,2000,231(1): 51-58.
  • 3Agaimy A, Wtinsch PH. Lymph node metastasis in gas- trointestinal stromal tumours (GIST) occurs preferentially in young patients < or = 40 years: an overview based on our case material and the literature[J]. Langenbecks Arch Surg,2009,394(2):375-381.
  • 4Tashiro T, Hasegawa T, Omatsu M, et al. Gastrointestinal stromal tumour of the stomach showing lymph node metastases[J]. Histopathology,2005,47(4):438-439.
  • 5Aparicio T, Boige V, Sabourin JC, et al. Prognostic factors after surgery of primary resectable gastrointestinal stromal tumours[J]. Eur J Surg Oncol,2004,30(10):1098-1103.
  • 6Fletcher CD, Berman JJ, Corless C, et al. Diagnosis of gastrointestinal stromal tumors: a consensus approach[J]. Int J Surg Pathol, 2002,10(2):81-89.
  • 7侯英勇,朱雄增.胃肠间质瘤恶性程度的判断及其对预后的影响[J].中国实用外科杂志,2010,30(4):265-269. 被引量:17
  • 8Prakash S, Sarran L, Socci N, et al. Gastrointestinal stro- real tumors in children and young adults: a clinicopatho- logic, molecular, and genomic study of 15 cases and re- view of the literature[J]. J Pediatr Hematol 0ncol,2005,27 (4):179-187.
  • 9Carney JA. Gastric stromal sarcoma, pulmonary chondroma and extra-adrenal paraganglioma (Carney Triad): natural history, adrenoeortieal component and possible familial oc- currence[J]. Mayo Clin Proc, 1999,74(6):543-552.
  • 10Carney JA, Sheps SG, Go VLW, et al. The triad of gastric leiomyosarcoma, functioning extra-adrenal paraganghoma and pulmonary chondroma[J]. N Engl J Med,1977,296(26): 1517-1518.

二级参考文献44

  • 1贺慧颖,方伟岗,钟镐镐,李燕,郑杰,杜娟,衡万杰,吴秉铨.165例胃肠道间质瘤中c-kit和PDGFRA基因突变的检测和临床诊断意义[J].中华病理学杂志,2006,35(5):262-266. 被引量:73
  • 2詹文华,王鹏志,邵永孚,伍晓汀,顾晋,李荣,万德森,丁克峰,师英强,于吉人,卢辉山,邹小明,毕建威,孙益红,陆云飞,陈道达,张信华.伊马替尼术后辅助治疗胃肠间质瘤的多中心前瞻性临床试验中期报告[J].中华胃肠外科杂志,2006,9(5):383-387. 被引量:85
  • 3Miettinen M, Lasota J. Gastrointestinal stromal tumors: review on morphology, molecular pathology, prognosis, and differential diagnosis. Arch Pathol Lab Med, 2006, 130(10) : 1466-1478.
  • 4Tashiro T, Hasegawa T, Omatsu M, et al. Gastrointestinal stromal tumour of the stomach showing lymph node metastases. Histopathology, 2005,47 (4): 438-439.
  • 5Aparicio T, Boige V, Sabourin JC, et al. Prognostic factors after surgery of primary resectable gastrointestinal stromal tumours. Eur J Surg Oncol, 2004, 30(10) :1098-1103.
  • 6El Demellawy D, Shokry P, Ing A, et al. Polypoid gastrointestinal stromal tumor of small bowel metastasizing to mesenteric lymph nodes: a case report. Pathol Res Pract, 2008, 204(3) :197-201.
  • 7Hu X, Forster J, Damjanov I. Primary malignant gastrointestinal stromal tumor of the liver. Arch Pathol Lab Med, 2003, 127 (12) : 1606-1608.
  • 8Sato T, Kanda T, Nishikura K, et al. Two cases of gastrointestinal stromal tumor of the stomach with lymph node metastasis. Hepatogastroenterology, 2007, 54 (76) : 1057-1060.
  • 9Sakurai N, Yamauchi J, Shibuma H, et al. A case of recurrent GIST of the esophagus which completely responded to imatinib mesilate. Gan To Kagaku Ryoho, 2007, 34 (2) :237-240.
  • 10Asakage N, Kobayashi S, Gotou T, et al. Two cases of gastrointestinal stromal tumor (GIST) of the stomach and a consideration of its malignancy potential and treatment strategyreport of two cases. Gan To Kagaku Ryoho, 2007,34 (6) : 919- 923.

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