胰腺癌的放射治疗进展

Development of radiation therapy for pancreatic carcinoma

胰腺癌高度恶性，手术可切除率低。放射治疗通过射线作用于肿瘤细胞DNA，引起细胞死亡以达到治疗目的，将其与化学治疗相联合的辅助治疗，对胰腺癌的综合治疗具有重要意义。该文回顾了近年来放射治疗在胰腺癌术前新辅助治疗、术后辅助治疗以及局部进展期治疗等方面取得的进展。放、化疗联合治疗对于不可切除胰腺癌病例的治疗意义尚需要更多更为可靠的循证医学证据来明确。

Adenocarcinoma of exocrine pancreas is a highly malignant tumor with extremely low resectability. Radiotherapy, by inducing necrosis and apoptosis of tumor cells through irradiation effects on cdlular DNA, in combination with chemotherapy, has made great contribution to muhimodal treatment of this malignancy. The development of radiation therapy for pancreatic carcinoma in recent years was reviewed in neoadjuvant and adjuvant settings, and for locally advanced disease. Further evidence is required to show the impact of radiochemotherapy in the treatment of unresectable disease.