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盐酸氨基乙酰丙酸介导的635/670nm联合波长下光动力学治疗的抗肿瘤效应 被引量：1

Irradiation at 635/670nm in 5-aminolevulinic acid-mediated photodynamic therapy:the anti-tumor effect
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摘要 目的通过实时测定单态氧(singlet oxygen,1 O2)评估635nm和(或)670nm激光照射下盐酸氨基乙酰丙酸(5-aminolevulinic acid,5-ALA)介导的光动力学治疗(photodynamic therapy,PDT)抗肿瘤效果。方法以5-ALA为光敏剂,在单波长(635nm或670nm)及联合波长(635nm+670nm)下进行激光照射,利用新型高灵敏的检测系统测定PpIX溶液、肿瘤细胞(9L神经胶质肉瘤细胞和HeLa细胞)及HeLa负瘤裸鼠中的1 O2强度,H-E染色法检测肿瘤组织坏死深度。结果接受单一的635nm或670nm波长激光照射时,PpIX溶液1 O2强度在两者中无明显区别。635nm与670nm激光联合照射下,9L细胞的1 O2强度高于HeLa细胞;在两种细胞中670nm激光诱发1 O2强度均远远低于635nm激光。在HeLa细胞裸鼠皮下移植瘤中,两种波长激光联合照射产生一定的肿瘤坏死深度,但低于635nm单波长照射。结论在5-ALA介导的PDT中,670nm波长激光显示了一定的PDT疗效。
作者 吴英鹰 黄光武 张哲
机构地区 广西医科大学第一附属医院耳鼻喉科广西卫生厅重点学科及重点实验室
出处 《第二军医大学学报》 CAS CSCD 北大核心 2011年第11期1263-1266,共4页 Academic Journal of Second Military Medical University
关键词 光动力学治疗 单态氧离子 抗肿瘤效应
分类号 R730.5 [医药卫生—肿瘤]
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参考文献11

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同被引文献7

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第二军医大学学报
2011年 第11期

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