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白介素-10在脑卒中后免疫抑制中的作用 被引量：5

Role of IL-10 in stroke-induced immunodepression syndrome
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摘要 脑卒中后感染及其发病机制,尤其是脑卒中诱导的免疫抑制这一概念是目前一个研究热点。白介素10(IL-10)作为一个抑制性细胞因子在脑卒中后免疫抑制中发挥着重要作用。本文就白介素10在脑卒中后的产生及生物学功能进行综述。 Stroke-induced immunodepression syndrome and its mechanism is a research focus in recent years. Interleukin-lO,as an inhibitory interleukin,takes an important part in stroke-induced immunodepression syndrome. This paper will elaborate the generation of IL-10 in human and its biological function after stroke.
作者 马嘉 闫福岭
机构地区 东南大学医学院神经内科 东南大学附属中大医院神经内科
出处 《中华脑血管病杂志（电子版）》 2011年第5期49-52,共4页 Chinese Journal of Cerebrovascular Diseases(Electronic Edition)
关键词 脑卒中后免疫抑制 交感神经系统 下丘脑-垂体-肾上腺轴 白介素10 Stroke induced immunodepression syndrome Sympathetic nervous system hypo- thalamo-pituitary-adrenal axis Interleukin-10
分类号 R743.3 [医药卫生—神经病学与精神病学]
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参考文献18

  • 1Woiciechowsky C, Asadullah K, Nestler D, et al. Sympathetic activa- tion triggers systemic interleukin-10 release in immunodepression induced by brain injury. Nature Med, 1998,4 (7) :808-813.
  • 2Dantzer R, O' Connor JC, Freund GG, et al. From inflammation to sickness and depression:When the immune system subjugates the brain. Nature Reviews Neurosci ,2008,9( 1 ) :46-56.
  • 3Emsley HC, Hopkins SJ. Acute ischaemic stroke and infection : recent and emerging concepts. Lancet Neuro1,2008,7 (4) :341-353.
  • 4Offner H, Subramanian S, Parker SM, et al. Experimental stroke induces massive, rapid activation of the peripheral immune system. J Cereb Blood Flow Metab,2006,26(5 ) :654-665.
  • 5Offner H, Subramanian S, Parker SM, et al. Splenic atrophy in experimental stroke is accompanied by increased regulatory T cells and circulating macrophages. J Immunol ,2006,176 ( 11 ) :6523-6531.
  • 6Prass K, Braun JS, Dirnagl U, et al. Stroke propagates bacterial aspiration to pneumonia in a model of cerebral ischemia. Stroke ,2006,37 (10) :2607-2612.
  • 7Chamorro A, Urra X, Planas AM. Infection after acute ischemic stroke:a manifestation of brain-induced immunodepression. Stroke, 2007,38(3) :1097-1103.
  • 8Woiciechowsky C, Schoning B, Daberkow N, et al. Brain IL-1β in- duces local inflammation but systemic anti-inflammatory responsethrough stimulation of both hypothalamic-pituitary-adrenal axis and sympathetic nervous system. Brain Research, 1999,816 ( 2 ) : 563- 571.
  • 9Woiciechowsky C, Schoning B, Wolfgang R, et al. Catecholamine-in- duced interleukin-10 release: a key mechanism in systemic immu- nodepression after brain injury. Crit Care, 1999,3 (6) : RI07-R111.
  • 10Chamorro A, Amaro S ,Vargas M ,et al. Interleukin 10, monocytes and increased risk of early infection in ischaemic stroke. J Neurol Neurosurg Psychiatry ,2006,77 ( 11 ) : 1279-1281.

二级参考文献19

  • 1Schwab JM, Nguyen TD, Meyermann R, et al. Human focal cerebral infarctions induce differential lesional interleukin-16 (IL-16) expression confined to infiltrating granulocytes, CD8 + T-lymphocytes and activated microglia/macrophages. J Neuroimmunol, 2001,
  • 2Beech JS, Reckless J, Mosedale DE, et al. Neuroprotection in ischemia-reperfusion injury: an antiinflammatory approach using a novel broad-spectrum chemokine inhibitor. J Cereb Blood Flow Metab,2001, 21: 683 -689.
  • 3Montaner J, Alvarez-Sabin J, Barbera G, et al. Correlation between the expression of proinflammatory cytokines and matrix metalloproteinases in the acute phase of an ischemic stroke. Rev Neurol, 2001,33:115 - 118.
  • 4Chen P, Shibata M, Zidovetzki R, et al. Endothelin-1 and monocyte chemoattractant protein-1 modulation in ischemia and human brainderived endothelial cell cultures. J Neuroimmunol, 2001, 116:62 -73.
  • 5Vila N, Castillo J, Davalos A, et al. Levels of anti-inflammatory cytokines and neurological worsening in acute ischemic stroke. Stroke,2003, 34:671 -675.
  • 6Boutin H, LeFeuvre RA, Horai R, et al. Role of IL-1 alpha and ILlbeta in ischemic brain damage. J Neurosci, 2001,21: 5528 - 5534.
  • 7Grau AJ, Reis A, Buggle F, et al. Monocyte function and plasma levels of interleukin-8 in acute ischemic stroke. J Neurol Sci, 2001,192:41 -47.
  • 8Kostulas N, Petidou SH, Kivisakk P, et al. Increased IL-lbeta, IL-8,and IL-17 mRNA expression in blood mononuclear cells observed ina prospective ischemic stroke study. Stroke, 1999, 30:2174 -2179.
  • 9Jander S, Schroeter M, Stoll G. Interleukin-18 expression after focal ischemia of the rat brain: association with the late-stage inflammatory response. J Cereb Blood Flow Metab, 2002, 22:62 -70.
  • 10Spera PA, Ellison JA, Feuerstein GZ, et al. IL-10 reduces rat brain injury following focal stroke. Neurosci Lett, 1998, 251: 189 - 192.

共引文献18

同被引文献74

引证文献5

二级引证文献11

中华脑血管病杂志（电子版）
2011年 第5期

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