抗CCP、AKA、RF联合诊断类风湿性关节炎

Combined dianosis of rheumatoid arthritis by anti-cyclic citrullinated peptide antibodies,anti-keratin antibodies and rheumatoid factor

目的:评价抗环瓜氨酸肽(CCP)抗体、抗角蛋白抗体(AKA)和类风湿性关节炎因子(RF)在类风湿性关节炎(RA)诊断中的意义。方法:127例RA患者、80例其他疾病患者和40例健康对照组血清检测上述项目,比较单独或联合检测对诊断RA的评价。结果:抗CCP、AKA阳性均出现于RA组,但也出现于其他疾病者组,RF除出现于上述两组外,还出现于健康对照组;故单独一项诊断RA,特异性很低。三种抗体联合检测诊断RA组,特异性可达到98.33%。结论:抗CCP、AKA、RF联合检测有利于诊断RA。

Objective：To evaluate the significance of anti-cyclic citrullinated peptide（CCP） antibody,anti-keratin antibodies（AKA） and rheumatoid factor（RF） in rheumatoid arthritis（RA） diagnosis.Methods： Serum is derived from 127 patients with RA,80 patients with other diseases and 40 healthy controls for detection of anti-CCP antibodies,AKA and RF,comparing their use in the diagnosis of RA.Results： Positive results of anti-CCP and anti-AKA not only appears in RA group,but also appears in patients with other disease.The positive results of RF not only appears in patients with RA and other diseases,but also appears in healthy group.Therefore,the specificity of RA diagnosis with anti-CCP,anti-AKA or RF alone is very low,while the specificity of combined diagnosis with three antibodies in RA can reach 98.33%.Conclusion： Anti-CCP,anti-AKA,RF combined detection is favorable to diagnosis of RA.