温州地区1268对行IVF/ICSI治疗夫妇HBV感染状况分析

Study on epidemiology of Hepatitis B Virus in 1268 couples undergoing IVF/ICSI in Wenzhou area

目的:了解温州地区行IVF/ICSI治疗患者乙肝病毒感染状况。方法:标本来源于2008年1月-2010年12月在温州医学院附属第二医院生殖中心行IVF/ICSI治疗的1268对夫妇,ELISA法检测乙肝病毒血清五项标志物,分析其HBV感染模式。结果:IVF/ICSI人群HBsAg阳性率为12.89%,男性阳性率为15.14%,显著高于女性的10.65%;IVF/ICSI夫妇一方阳性的比例为24.61%;共发现15种感染模式,主要感染模式有8种。结论:温州地区IVF/ICSI人群慢性HBV携带率可能高于普通人群,男性HBsAg阳性率高于女性,感染模式呈现多样性。

Objective：To investigate the serological infection rate of Hepatitis B Virus（HBV） in couples following IVF/ICSI.Methods： During the period from January 2008 to December 2010,1268 couples who visited The Assisted Reproductive Center of The Second Affiliated Hospital of Wenzhou Medical College were taken into the study.All the subjects were routinely screened for HBsAg in the serum via enzyme immunoassay.Results： No significant difference on mean age exists between males and females in IVF/ICSI couples（P0.05）.HBsAg seropositive rate is 12.89% in IVF/ICSI population,and HBsAg seropositive of males is 15.14%,significantly higher than that in females（10.65%）.The proportion of IVF/ICSI couples with one partner showing HBsAg positive is 24.61%.15 infection models were found in total,in which 8 were dominant.Conclusion： In Wenzhou,proportions of chronic HBV carriers in IVF/ICSI population are higher than that in general population.HBsAg seropositive rate in males is higher than in females.Moreover,the infection mode is diversity.