摘要
The crystal structure of the title compound （C7H14N2O7P2, Mr = 300.14） was determined by single-crystal X-ray diffraction. The crystal belongs to triclinic, space group P1 with a = 8.258（3）, b = 8.886（3）, c = 9.275（3） A, a = 96.669（3）, β = 115,706（3）, γ= 104.467（3）°, V= 573.8（3） A^3, Z = 2, Dc = 1.737 g/cm^3, 2（MoKa） = 0.71073, F（000） = 720,μ（MoKa） = 0.41 mm^-1 R = 0.030 and wR = 0.078. A total of 1970 unique reflections were collected, of which 1742 with I 〉 2σ（I） were observed. EIDHP has a structure similar to zoledronic acid （ZL）. ZL is a potent bone antiresorptive bisphosphonate drug having significant activity against several parasitic protozoa. EIHDP has inner-salt character, consisting of a negatively charged PO3 group and a positively charged N（1） atom. The crystal structure is stabilized by interrnolecular hydrogen bonds of O-H…O and N-H…O.
The crystal structure of the title compound （C7H14N2O7P2, Mr = 300.14） was determined by single-crystal X-ray diffraction. The crystal belongs to triclinic, space group P1 with a = 8.258（3）, b = 8.886（3）, c = 9.275（3） A, a = 96.669（3）, β = 115,706（3）, γ= 104.467（3）°, V= 573.8（3） A^3, Z = 2, Dc = 1.737 g/cm^3, 2（MoKa） = 0.71073, F（000） = 720,μ（MoKa） = 0.41 mm^-1 R = 0.030 and wR = 0.078. A total of 1970 unique reflections were collected, of which 1742 with I 〉 2σ（I） were observed. EIDHP has a structure similar to zoledronic acid （ZL）. ZL is a potent bone antiresorptive bisphosphonate drug having significant activity against several parasitic protozoa. EIHDP has inner-salt character, consisting of a negatively charged PO3 group and a positively charged N（1） atom. The crystal structure is stabilized by interrnolecular hydrogen bonds of O-H…O and N-H…O.
基金
supported by the Science Foundation of the Health Department of Jiangsu Province (No. H200934)
