咀嚼对脑血流动力学影响的临床实验研究

Clinical experimental study on the effects of mastication on the dynamics of cerebral blood flow

目的观察正常受试者咀嚼运动前后脑血流的改变,探讨咀嚼对脑血流动力学的影响及意义。方法应用经颅彩色多谱勒超声扫描仪(transcranial color doppler,TCCD),探测30名正常受试者在安静状态下和咀嚼无糖口香糖10分钟后脑血流速的改变,对大脑中动脉收缩期峰流速(systolic peak flow velocity,Vs)、舒张期末峰流速(enddiastolic peak flow velocity,Vd)、平均峰流速(mean peak flow velocity,Vm)进行统计分析。结果①30名受试者咀嚼前脑血流速值均数(单位:cm/s):收缩期峰流速(Vs)-91.785,舒张期末峰流速(Vd)-39.385,平均峰流速(Vm)-55.735;咀嚼后均数:收缩期峰流速(Vs)-103.030,舒张期末峰流速(Vd)-46.015,平均峰流速(Vm)-64.090;②经两样本均数t检验可知咀嚼前后的大脑中动脉的收缩期峰流速(Vs)、舒张期末峰流速(Vd)、平均峰流速(Vm)的结果在男性与女性之间均无显著性差异(P>0.05);③受试者咀嚼前后配对t检验结果显示,受试者咀嚼后大脑中动脉收缩期峰流速(Vs)、舒张期末峰流速(Vd)及平均峰流速(Vm)与咀嚼前相比均有显著性差异(P<0.05)。结论咀嚼可使大脑中动脉血管充盈度增加,血流速度显著加快。

Objective To observe the cerebral blood flow changes of normal occlusion subjects before and after the movement of chewing,and to investigate the effects and significance of chewing on cerebral blood flow dynamics.Methods Transcranial Color Doppler（TCCD） was used to detect the changes of cerebral blood flow in 30 normal occlusion subjects in a quiet state and 10 minutes after chewing sugarless gum,and the systolic peak flow velocity（Vs）,enddiastolic peak flow velocity（Vd）,mean peak flow velocity（Vm） were all statistically analyzed.Results ①The mean value of cerebral blood flow of 30 subjects before chewing（unit： cm/s）： systolic peak flow velocity（Vs）-91.785,enddiastolic peak flow velocity（Vd）-39.385,and mean peak flow velocity（Vm）-55.735;mean value after chewing： systolic peak flow velocity（Vs）-103.030,enddiastolic peak flow velocity（Vd）-46.015,and mean peak flow velocity（Vm）-64.090.②T-test of the two independent samples showed that the results of systolic peak flow velocity（Vs）,enddiastolic peak flow velocity（Vd）,mean peak flow velocity（Vm） had no significant difference between men and women,（P〈0.05）.③The paired t-test showed that systolic peak flow velocity（Vs）,enddiastolic peak flow velocity（Vd）,and mean peak flow velocity（Vm） had significant difference before and after chewing（P〈0.05）.Conclusion Chewing can increase the filling degree of cerebral artery and make blood flow significantly faster.