59例肝转移瘤超级伽玛刀治疗临床疗效分析

Clinical analysis of super gama knife for 79 cases of metastatic liver cancer

目的探讨超级伽玛刀对肝转移瘤的治疗效果。方法回顾分析我院2006年1月—2010年3月收治的59例肝转移瘤患者(103个转移灶),肿瘤的临床靶体积(CTV)为1.2～247 cm3(平均55.9 cm3),计划靶体积(PTV)周边剂量为每次照射3～6 Gy(平均4.8 Gy),PTV中心剂量为每次照射6～10 Gy(平均8.2 Gy),每天1次,每周5次,共5～12次。结果总有效率(完全缓解+部分缓解)为88.1%。6个月、1年、2年生存率分别为93.0%、72.2%3、1.6%。结论伽玛刀治疗是治疗肝转移瘤的有效方法。

Objective To evaluate the therapeutic effect of super gama knife on metastatic hepatic cancer. Methods From January 2006 to March 2010,59 patients with metastatic liver cancer（103 metastases） were treated by super gama knife.The clinical target volume（CTV） of tumor ranged from 1.2 cm3 to 247 cm3（the mean： 55.9 cm3）,peripheral irradiation doses of planning target volume（PTV） ranged from 3 Gy to 6 Gy（the mean： 4.8 Gy） each time,and entail irradiation doses of PTV were 6 Gy to 10 Gy（the mean： 8.2 Gy） each time,once a day for 5 times to 12 times totally. Results The whole effective rate（CR＋PR） was 88.1%.The six-month,one-year,two-year survival rate were 93.0%,72.2%,31.6%,respectively. Conclusions The super gama knife is an effective treatment for tometastatic liver cancer.