摘要
目的探讨血清脑利钠肽(BNP)浓度在儿童心力衰竭(心衰)时的变化及诊断价值。方法应用ELISA法测定40例心衰患儿(心衰组)和30例无心衰患儿(对照组)的血清BNP浓度,采用二维超声心动图测定相应的左室射血分数(EF)、左室短轴缩短率(FS)值。结果心衰组血清BNP为(426.73±249.73)pg/ml,明显高于对照组的(36.00±4.08)pg/ml(P<0.05)。BNP水平与NYHA分级和改良ROSS标准呈正相关(P<0.01),与EF、FS呈负相关(P<0.01)。结论测定血清BNP浓度有助于早期诊断儿童心力衰竭。
Objective To evaluate the changes and diagnostic value of plasma brain natriretic peptide（BNP） in children with heart failure（HF）. Methods Using ELISA and 2D echo,serum BNP and left ventricular ejection fraction（EF） and fractional shortening（FS） were measured in 40 HF children（group HF） and 30 children without HF（group C）. Results Serum BNP was higher in group HF than that in group C [（426.73±249.73）pg/ml vs.（36.00±4.08）pg/ml]（P0.05）. Serum BNP was positively correlated to NYHA grading and modified ROSS standard,but negatively correlated to EF and FS（P0.01）. Conclution Detecting serum BNP is healpful in the early diagnosis of HF in children.
出处
《江苏医药》
CAS
CSCD
北大核心
2011年第22期2659-2660,共2页
Jiangsu Medical Journal
关键词
脑利钠肽
心力衰竭
儿童
Brain natriuretic peptide
Heart failure
Children
