摘要
肠易激综合征(IBS)是一种个体特异性、多病因的异质性疾病,其发病和患者的精神状态、社会环境、生活应激等多种心理社会因素密切相关。促肾上腺皮质激素释放因子(CRF)是一种介导下丘脑-垂体-肾上腺(HPA)轴对应激反应的关键调节肽,参与脑-肠轴互动,通过影响胃肠道动力、内脏高敏感和肠道感染等参与IBS的发病。
Irritable bowel syndrome (IBS) is a heterogeneous disease. The occurence of IBS is related to patient's mental status, social environment, life stress events and the other psychosocial factors. Corticotropin-releasing fac- tor (CRF) is a key regulatory peptide in mediating the hypothalamus-pituitary-adrenal axis' response to stress and involves in the brain-gut axis interactions. CRF might be involved in IBS pathogenesis by altering gastrointestinal motility, visceral sensitivity, and the inflammation in the bowel.
出处
《基础医学与临床》
CSCD
北大核心
2011年第12期1396-1399,共4页
Basic and Clinical Medicine
基金
"十一五"国家科技支撑计划课题(2007BAI04B01)