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促肾上腺皮质激素释放因子与肠易激综合征 被引量：12

Corticotropin-releasing factor and irritable bowel syndrome
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摘要 肠易激综合征(IBS)是一种个体特异性、多病因的异质性疾病,其发病和患者的精神状态、社会环境、生活应激等多种心理社会因素密切相关。促肾上腺皮质激素释放因子(CRF)是一种介导下丘脑-垂体-肾上腺(HPA)轴对应激反应的关键调节肽,参与脑-肠轴互动,通过影响胃肠道动力、内脏高敏感和肠道感染等参与IBS的发病。 Irritable bowel syndrome （IBS） is a heterogeneous disease. The occurence of IBS is related to patient＇s mental status, social environment, life stress events and the other psychosocial factors. Corticotropin-releasing fac- tor （CRF） is a key regulatory peptide in mediating the hypothalamus-pituitary-adrenal axis＇ response to stress and involves in the brain-gut axis interactions. CRF might be involved in IBS pathogenesis by altering gastrointestinal motility, visceral sensitivity, and the inflammation in the bowel.
作者 常敏 方秀才
机构地区 中国医学科学院北京协和医学院北京协和医院消化内科
出处 《基础医学与临床》 CSCD 北大核心 2011年第12期1396-1399,共4页 Basic and Clinical Medicine
基金 "十一五"国家科技支撑计划课题(2007BAI04B01)
关键词 肠易激综合征 促肾上腺皮质激素释放因子 应激 irritable bowel syndrome corticotropin-releasing factor stress
分类号 R574.4 [医药卫生—消化系统]
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参考文献19

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二级参考文献11

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基础医学与临床
2011年 第12期

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