CCT亚基γ在人肝细胞癌组织中的表达及意义

Significance of expression of CCT subunit γ in human hepatocellular carcinoma

目的:探讨CCT亚基γ在人肝细胞癌组织中的表达和意义.方法:用免疫组织化学一步法检测35例肝癌及癌旁组织、12例正常肝组织中的CCT亚基γ表达.结果:CCT亚基γ在肝癌组织的阳性表达率为88.57%(31/35),在癌旁组织中的阳性表达率为62.86%(22/35),在正常肝组织中的阳性表达率为41.67%(5/12).CCT亚基γ在肝癌组织中的表达明显高于癌旁组织和正常肝组织,具有显著性差异(P<0.05).CCT亚基γ的表达与肝癌患者年龄、乙肝表面抗原、有无门静脉癌栓、AFP水平、肿瘤直径及临床分期均不相关(P>0.05),但CCT亚基γ的过度表达与肝癌患者肿瘤细胞分化程度相关(P<0.05),肿瘤细胞分化程度越低,CCT亚基γ的表达越高.结论:CCT亚基γ在人肝细胞癌组织中表达增高可能与肝细胞的癌变有关.

AIM：To evaluate the signif icance of expressionof CCT subunit γ in human hepatocellular carcinoma（HCC）.METHODS：The expression of CCT subunit γwas detected by immunohistochemistry in 35cases of HCC and tumor adjacent tissue and 12cases of normal liver tissue.RESULTS：The positive rate of CCT subunit γexpression in HCC was signif icantly higher thanthose in tumor adjacent and normal liver tissues（88.57% vs 62.86%,41.67%,both P 0.05）.The expression of CCT subunit γ was not correlated with age,hepatitis B surface antigen,portal venous tumor emboli,AFP level,tumor size or clinical stage（all P 0.05）,but was negatively correlated with tumor differentiation（P 0.05）.CONCLUSION：CCT subunit γ is overexpressed in HCC,and CCT overexpression may be related with HCC carcinogenesis.