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选择性COX-2抑制剂对大鼠局灶性脑缺血再灌注损伤的保护作用 被引量：2

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摘要 目的观察诱导型环加氧酶(COX-2)抑制剂对大鼠局灶性脑缺血再灌注损伤(CIRI)的保护作用,探讨其可能机制。方法线栓法制备大鼠大脑中动脉闭塞2h/再灌注24h模型,治疗组在再灌注同时灌胃给予罗非昔布(Rofe-coxib)2.24mg/kg,对照组给予等容量生理盐水。免疫组化法测定脑组织中COX-2表达情况,用软件计算脑梗死面积,测定脑组织NO含量及NOS活性变化。结果 CIRI后脑组织COX-2表达增加,Rofecoxib 2.24mg/kg可有效抑制COX-2活性,能明显缩小脑梗死灶,降低NOS活性及NO含量。结论 Rofecoxib对大鼠局灶性脑缺血/再灌注损伤有保护作用。
作者 陈柏龄
机构地区 福建医科大学附属漳州市医院神经内科
出处 《海峡预防医学杂志》 CAS 2011年第5期43-45,共3页 Strait Journal of Preventive Medicine
关键词 局灶性脑缺血 诱导型环加氧酶(COX-2) 罗非昔布(Rofecoxib) 大鼠 动物实验
分类号 R743.31 [医药卫生—神经病学与精神病学] R-322 [医药卫生]
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参考文献9

  • 1周宇,余涓,邱丽颖,陈崇宏.褪黑素对大鼠急性脑缺血再灌注损伤保护作用研究[J].中国药理学通报,2003,19(2):194-196. 被引量：14
  • 2O'Neill GP,Ford-Hutehinson AW. Expression of mRNA for cyclooxygenase-1 and cyclooxygenase-2 in human tissues[J]. FEBS Lett, 1993,330(2) : 156-160.
  • 3Dubois RN, Abramson SB, Crofford L, et al. Cyclooxygenase in biology and disease [J]. FASEB J,1998,12(12) :1063-1073.
  • 4Kinoshita Y,Ueyama T, Senba E, et al. Expression of c-fos, heat shock protein 70,neurotrophinsm and cyclooxygenase-2 mRNA in response to focal cerebral ischemia/reperfusion in rats and their modification by magnesium sulfate[J]. Neurotrauma, 2001, 18 (4) ,435-445.
  • 5Iadecola C,Niwa K,Nogawa S,et al. Reduced susceptibility to ischemic brain injury and N-methyl-D-aspartate-mediated neurtoxicity in cyclooxygenase-2-deficient mice[J]. Proc Natl Acad Sci- USA,2001,98(3) : 1294-1299.
  • 6Nogawa S,Zhang F,Ross ME,et al. Cyclo-oxygenase-2 gene expression in neurons contributes to ischemie brain damage[J]. J Neurosci,1997,17(8) :2746-2755.
  • 7Govoni S, Masoero E, Favalli L, et al. The Cycloxygenase-2 inhibitor SC58236 is neuroprotective in an in vivo model of focal ische-mia in the rat[J]. Neurosci Lett, 2001,303 (2) : 91-94.
  • 8罗玉敏,秦震,陈俊.选择性COX2抑制剂对脑缺血再灌注损伤的影响[J].中国临床神经科学,2001,9(2):133-135. 被引量：4
  • 9Iadeeola C, Forster C, Nogawa S, et al. Cyclooxygenase-2 immunoreactivity in the human brain following cerebral isehemia [J]. Aeta Neuropathol (Berl) ,1999,98(1) :9-14.

二级参考文献12

  • 1[1]Nogawa S, Zhang F, Ross E, et al. Cyclo-oxygenase-2 gane expression inneurons contributes to ischemic brain damage. J Neurosci, 1997; 14:2746-2755
  • 2[2]Kujubu DA, Fletcher BS, Vamum BC, et al. TIS10, a phorbol estersynthase/cyclooxygenade homologue. J Biol Chem, 1991; 266:12866-12872
  • 3[3]Xie W, Merrill JR, Bradshaw WS, et al. Structural determination andpromoter analysis of the chicken mitogen-inducible prostaglandin G/Hsynthase gene and genetic mapping of the murine homolog. Arch BiochemBiophys, 1993; 300:247-252
  • 4[4]Feng L, Sun W, Xia Y, et al. Cloning two isoforms of rat cyclooxygenase:differential regulation of their expression. Arch Biochem Biophys, 1993;307: 361-368
  • 5[5]Gierse JK, McDonald JJ, Hauser SD, et al. A single amino acid differencebetween cyclooxygenase-1 (COX-1) and-2 (COX-2) reverses the selectivityof COX-2 specific inhibitors. J Biol Chem, 1996; 271:15810-15814
  • 6[6]Smith WL, Garavito RM and DeWitt DL. Prostaglandin endoperoxide Hsynthases (cyclooxygenases)-1 and-2. J Biol Chem, 1996; 271:33157-33160
  • 7[7]Kurumbail RG, Stevens AM, Gierse JK, et al. Structure basis for selectiveinhibition of cyclooxygenase-2 by anti-inflammatory agents. Nature, 1996;384:644-648
  • 8[8]Loll PJ, Picot D and Garavito RM. The structure basis of aspirin activityinferred from the crystal structure of inactivated prostaglandin H2 synthase.Nat Struct Biol, 1995; 2:637-643
  • 9[9]Mitchell JA, Akarasereenont P, Thiemermann C, et al. Selectivity ofnonsteroidal antiinflammatory drugs as inhibitors of constitutive and induciblecyclooxygenase. Proc Natl Acad Sci USA, 1993; 90:11693-11697
  • 10[10]Meade EA, Smith WL and DeWitt DL. Differential inhibition of prostaglandinendoperoxide synthase (cyclooxygenase) isozymes by aspirin and other non-steroidal anti-inflammatory drugs. J Biol Chem, 1993; 268:6610-6614

共引文献15

同被引文献31

  • 1North CS, Pfefferbaum B, Kawasaki A, et al. Psychosocial adjustment of directly exposed survivors 7 years 'after the Oklahoma City bombing [ J ]. Compr Psychiatry, 2011, 52 ( 1 ) : 1-8.
  • 2Petersen T, Elklit A, Olesen JG. Victimization and PTSD in a Faroese youth total-pnpulation sample [J]. Scand J Psychol, 2010, 51(1):56-62.
  • 3Smith AK, Conneely KN, Kilaru V, et al. Differential immune system DNA methylation and cytokine regulation in post-traumatic stress disorder [J]. Am J Med Genet B Neuropsychiatr Genet, 2011, 156B (6) : 700-708.
  • 4Hayley S, Poulter MO, Merali Z, et al. The pathogenesis of clinical depression: stressor- and cytnkine-indueed alterations of neuroplasticity [ J ]. Neuroscience, 2005, 135 (3) : 659-678.
  • 5Gola H, Engler H, Sommershof A, et al. Posttraumatic stress disorder is associated with an enhanced spontaneous production of pro-inflammatory cytokines by peripheral blood monouuclear cells [Jl. BMC Psychiatry, 2013, 29(9):13-40.
  • 6Babson KA, Feldner MT. Temporal relations between sleep problems and both traumatic event exposure and PTSD: a critical review of the empirical literature [J]. J Anxiety Disorders, 2010, 1(24): 11-15.
  • 7Boals A, Hathaway LM. The importance of the DSM-IV E and Fcriteria in self-report assessments of PTSD [J]. J Anxiety Bisord, 2010, 24(1): 161-166.
  • 8Bailey JN, Goenjian AK, Noble EP, et al. PTSD and dopaminergic genes, DRD2 and DAT, in muhigenerational families exposed to the Spitak earthquake [J]. Psychiatry Res, 2010, 178(3): 507-510.
  • 9Carpenter LL, Gawuga CE, Tyrka AR, et al. Association between plasma IL-6 response to acute stress and early-life adversity in healthy adults [J]. Neuropsyehopharmaeology, 2010, 35(13): 2617-2623.
  • 10Wilson CB, McLaughlin LD, Nair A, et al. Inflammation and oxidative stress are elevated in the brain, blood, and adrenal glands during the progression of post-traumatic stress disorder in a predator exposure animal model [J]. PLoS One, 2013, 8 (10) : e76146.

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海峡预防医学杂志
2011年 第5期

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