摘要
Background Diabetic retinopathy （DR） has emerged as a leading cause of visual impairment and blindness in the working-aged population worldwide. This study aimed to assess frequency and associated factors of progression of DR in subjects with known diabetes in a population-based setting. Methods The Beijing Eye Study is a population based study performed in Greater Beijing in 2001 and 2006. The present investigation included all subjects with known diabetes mellitus in 2001, who participated in the follow-up examination in 2006. Fundus photographs were assessed. Results The study included 170 subjects; 51 （30%） subjects showed signs of DR in 2001 and were re-examined in 2006, 36 （21.2%） subjects （18 subjects with DR present at baseline, 18 subjects with newly diagnosed DR in 2006） showed a progression of DR during follow-up. Progression of DR was associated with rural region （odds ratio （OR）： 5.43, P=0.001） and self-reported arterial hypertension （OR： 3.85, P=0.023）. In the non-progressive subgroup, presence of DR was associated with different levels of education （〈middle school, middle school, college or higher, OR： 0.30, P=-0.023）, treatment modes of diabetes mellitus （OR： 10.24, P=0.003） and cataract surgery （OR： 9.14, P=0.007）. Conclusions In a population-based setting in Greater Beijing, progression of DR occurred in 35% of subjects with pre-existing DR and overall in 21% of subjects with known diabetes within a 5-year period. Progression of DR was significantly associated with rural region and self-reported arterial hypertension. In the stable subjects, presence of DR was significantly associated with poor educational level, insulin treatment of diabetes and cataract surgery.
Background Diabetic retinopathy （DR） has emerged as a leading cause of visual impairment and blindness in the working-aged population worldwide. This study aimed to assess frequency and associated factors of progression of DR in subjects with known diabetes in a population-based setting. Methods The Beijing Eye Study is a population based study performed in Greater Beijing in 2001 and 2006. The present investigation included all subjects with known diabetes mellitus in 2001, who participated in the follow-up examination in 2006. Fundus photographs were assessed. Results The study included 170 subjects; 51 （30%） subjects showed signs of DR in 2001 and were re-examined in 2006, 36 （21.2%） subjects （18 subjects with DR present at baseline, 18 subjects with newly diagnosed DR in 2006） showed a progression of DR during follow-up. Progression of DR was associated with rural region （odds ratio （OR）： 5.43, P=0.001） and self-reported arterial hypertension （OR： 3.85, P=0.023）. In the non-progressive subgroup, presence of DR was associated with different levels of education （〈middle school, middle school, college or higher, OR： 0.30, P=-0.023）, treatment modes of diabetes mellitus （OR： 10.24, P=0.003） and cataract surgery （OR： 9.14, P=0.007）. Conclusions In a population-based setting in Greater Beijing, progression of DR occurred in 35% of subjects with pre-existing DR and overall in 21% of subjects with known diabetes within a 5-year period. Progression of DR was significantly associated with rural region and self-reported arterial hypertension. In the stable subjects, presence of DR was significantly associated with poor educational level, insulin treatment of diabetes and cataract surgery.
