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Correlation between 1,5-anhydroglucitol and glycemic excursions in type 2 diabetic patients 被引量:11

Correlation between 1,5-anhydroglucitol and glycemic excursions in type 2 diabetic patients
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摘要 Background The accurate and comprehensive assessment of glycemic control in patients with diabetes is important for optimizing glycemic management and for formulating personalized diabetic treatment schemes. This study aimed to analyze the correlation between 1,5-anhydroglucitol (1,5-AG) and glycemic excursions in type 2 diabetic patients. Methods Seventy-one outpatients with type 2 diabetes mellitus were randomly recruited from Chinese People's Liberation Army General Hospital. Using a continuous glucose monitoring system (CGMS), these patients' blood glucose levels were monitored for three consecutive days to obtain mean blood glucose (MBG) data. Intraday glycemic excursions were evaluated using the mean amplitude of glycemic excursions (MAGE), the largest amplitude of glycemic excursions (LAGE), standard deviation of blood glucose (SDBG) and the M-value. Interday glycemic excursion was assessed by absolute mean of daily difference (MODD). Postprandial glycemic fluctuations were evaluated using postprandial glucose excursions (PPGE) and postprandial incremental area under the curve (iAUC). Fasting venous blood samples were collected to measure serum 1,5-AG, whole-blood hemoglobin Alc (HbAlc) and serum glycated albumin (GA). Clinical markers of glycemia and parameters of glycemic excursions from CGMS were analyzed using the Pearson correlation coefficient and multivariate stepwise regression. Results Pearson correlation analysis revealed that 1,5-AG was significantly correlated with MAGE, SDBG, M-value, LAGE, PPGE and iAUC (r values were-0.509,-0.430,-0.530,-0.462,-0.416 and-0.435, respectively, P 〈0.01), especially in moderately and well-controlled patients, based on defined HbAlc levels. Multivariate stepwise regression analysis revealed a negative correlation between 1,5-AG and the above parameters, but not HbAlc and GA. Finally, HbAlc and GA were positively correlated with MBG and fasting blood glucose (FBG). Conclusions 1,5-AG was much better than HbAlc and GA as a marker of glycemic excursions in type 2 diabetic patients. Based on these results 1,5-AG is the best metric for assessing postprandial glucose levels in moderately and well-controlled patients, while HbAlc and GA were superior to 1,5-AG for monitoring MBG and FBG. Background The accurate and comprehensive assessment of glycemic control in patients with diabetes is important for optimizing glycemic management and for formulating personalized diabetic treatment schemes. This study aimed to analyze the correlation between 1,5-anhydroglucitol (1,5-AG) and glycemic excursions in type 2 diabetic patients. Methods Seventy-one outpatients with type 2 diabetes mellitus were randomly recruited from Chinese People's Liberation Army General Hospital. Using a continuous glucose monitoring system (CGMS), these patients' blood glucose levels were monitored for three consecutive days to obtain mean blood glucose (MBG) data. Intraday glycemic excursions were evaluated using the mean amplitude of glycemic excursions (MAGE), the largest amplitude of glycemic excursions (LAGE), standard deviation of blood glucose (SDBG) and the M-value. Interday glycemic excursion was assessed by absolute mean of daily difference (MODD). Postprandial glycemic fluctuations were evaluated using postprandial glucose excursions (PPGE) and postprandial incremental area under the curve (iAUC). Fasting venous blood samples were collected to measure serum 1,5-AG, whole-blood hemoglobin Alc (HbAlc) and serum glycated albumin (GA). Clinical markers of glycemia and parameters of glycemic excursions from CGMS were analyzed using the Pearson correlation coefficient and multivariate stepwise regression. Results Pearson correlation analysis revealed that 1,5-AG was significantly correlated with MAGE, SDBG, M-value, LAGE, PPGE and iAUC (r values were-0.509,-0.430,-0.530,-0.462,-0.416 and-0.435, respectively, P 〈0.01), especially in moderately and well-controlled patients, based on defined HbAlc levels. Multivariate stepwise regression analysis revealed a negative correlation between 1,5-AG and the above parameters, but not HbAlc and GA. Finally, HbAlc and GA were positively correlated with MBG and fasting blood glucose (FBG). Conclusions 1,5-AG was much better than HbAlc and GA as a marker of glycemic excursions in type 2 diabetic patients. Based on these results 1,5-AG is the best metric for assessing postprandial glucose levels in moderately and well-controlled patients, while HbAlc and GA were superior to 1,5-AG for monitoring MBG and FBG.
出处 《Chinese Medical Journal》 SCIE CAS CSCD 2011年第22期3641-3645,共5页 中华医学杂志(英文版)
关键词 1 5-ANHYDROGLUCITOL type 2 diabetes mellitus glycemic excursions 1,5-anhydroglucitol type 2 diabetes mellitus glycemic excursions
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  • 1Colette C,Monnier L.Acute glucose fluctuations and chronic sustained hyperglycemia as risk factors for cardiovascular diseases in patients with type 2 diabetes.Horm Metab Res 2007; 39:683-686.
  • 2Quagliaro L,Piconi L,Assalone R,Martinelli L,Motz E,Ceriello A.Intermittent high glucose enhances apoptosis related to oxidative stress in human umbilical vein endothelial cells:The roll of protein kinase C and NAD(P)H-oxidase activation.Diabetes 2003; 52:2795-2804.
  • 3DECODE Study Group,the European Diabetes Epidemiology Group.Glucose tolerance and cardiovascular mortality comparison of fasting and 2-hour diagnostic criteria.Arch Intern Med 2001; 161:397-405.
  • 4Hanefeld M,Fischer S,Julius U,Schulze J,Schwanebeck U,Schmechel H,et al.DIS Group.Risk factors for myocardial infarction and death in newly detected NIDDM:the Diabetes Intervention Study,11-year follow-up.Diabetologia 1996; 39:1577-1583.
  • 5UK Prospective Diabetes Study (UKPDS) Group.Intensive blood-glucose control with sulphonylureas or insulin compared with conventional treatment and risk of complications in patients with type 2 diabetes (UKPDS 33).Lancet 1998; 352:837-853.
  • 6Khaw KT,Wareham N,Bingham S,Luben R,Welch A,Day N.Association of hemoglobin Alc with cardiovascular disease and mortality in adults:the European prospective investigation into cancer in Norfolk.Ann Intern Med 2004;141:413-420.
  • 7Kishimoto M,Yamasaki Y,Kubota M.1,5-Anhydro-D-glucitol evaluates daily glycemic excursions in well-controlled NIDDM.Diabetes Care 1995; 18:1156-1159.
  • 8Dworacka M,Winiarska H.The application of plasma 1,5-anhydro-D-glucitol for monitoring type 2 diabetic patients.Dis Markers 2005; 21:127-132.
  • 9Service FJ,Molnar GD,Rosevear JW,Ackerman E,Gatewood LC,Taylor WF,et al.Mean amplitude of glycemic excursion,a measure of diabetic instability.Diabetes 1970;19:644-655.
  • 10Moanier L,Mas E,Ginet C,Michel F,Villon L,Cristol JP,et al.Activation of oxidative stress by acute glucose fluctuations compared with sustained chronic hyperglycemia in patients with type 2 diabetes.JAMA 2006; 295:1681-1687.

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