摘要
目的观察PM2.5对高血脂症大鼠心血管系统的影响,分析高血脂症大鼠是否存在易感性。方法高脂饲料喂养诱导高血脂症的Wistar大鼠和普通饲料喂养的Wistar大鼠各32只,采用气管滴注不同剂量的PM2.5进行染毒,通过检测染毒后大鼠血清心肌酶、C反应蛋白、血脂,测量血压、心率,观察不同浓度的PM2.5对心血管系统的影响。结果大鼠经PM2.5染毒后,高血脂症组与对照组相比,心肌激酶、C反应蛋白、血压和心率均有显著性差异(P<0.05),且随着PM2.5剂量的增加而升高。结论 PM2.5对正常和病理状态的大鼠心血管系统均有损伤作用,但对高血脂症大鼠心血管系统的影响明显高于正常大鼠,提示高血脂症大鼠受PM2.5影响具有易感性。
Objective To ohserve the effects of PM2.5 on cardiovascular system in high fat diet rats and to analysis whether there is susceptibility of high fat diet rats to PM2.5. Methods There were thirty two high fat diet induced hyperlipidemia Wistar rats and agematched thirty two normal diet Wistar rats in the study. Creatine kinase, C reactive protein, blood lipids, blood pressure and heart rate were tested in order to observe effects of different concentrations of PM2.5 on the cardiovascular system after rats＇ tracheas were exposed to different doses of PM2.5 by instillation. Results Creatine kinase, C - reactive protein, blood pressure and heart rate of hyperlipidemia group were significantly different from those of the control group （P 〈 0.05 ） , and above indicators were increased with the increase of the concentration of PM2.5. Conclusion The cardiovascular system of rats in normal and pathological state can be injured by PM2.5, hut the effect of PM2.5 on cardiovascular system of hyperlipidemia rats is more serious than that of normal rats. These results prompted hyperlipidemia rats is susceptible to PM2.5.
出处
《医学研究杂志》
2011年第11期32-34,共3页
Journal of Medical Research
基金
国家重点基础研究计划(973)项目资助(2011CB503803)
