纳米羟基磷灰石复合支架材料的研究与应用

Research progress of nano-hydroxyapatite composite scaffolds

背景:羟基磷灰石具有良好的生物相容性和生物活性,被广泛应用于骨组织的修复与替代技术,但脆性大限制了其在承载部位骨替换中的应用。目的:对纳米羟基磷灰石复合支架材料的研究现状与进展进行综述。方法:分别以英文检索词"nano-hydroxyapatite(nano-HA),composites";中文检索词"纳米羟基磷灰石,复合材料",应用计算机检索中国期刊网全文检索库(CNKI)及PubMed数据库1995-01/2010-10有关文章,纳入纳米羟基磷灰石复合材料的文献。排除与研究目的无关和内容重复者。保留33篇文献做进一步分析。结果与结论:随着纳米技术的发展,纳米羟基磷灰石复合支架材料中复合成分得以不断优化,能比较好的模仿天然骨和细胞外基质的结构特点,证明了其优越性,但仍需要进一步优化制备方法,增强纳米羟基磷灰石和生物高分子界面的结合,使复合材料的力学、加工性能和生物性能达到最佳契合点,从而达到临床使用的要求。

BACKGROUND： Hydroxyapatite has been widely used as reconstructive and prosthetic material for osseous tissue, owing to its excellent biocompatibility and bioactivity. But, its brittleness is one of the most serious obstacles for its wider applications as load-bearing implants. OBJECTIVE： To review various hydroxyapatite composites and the research progress in this field. METHODS： Articles were searched in PubMed database （1995-01/2010-10） and CNKI Database （1995-01/2010-10） with the Keywords of ＂nano-hydroxyapatite, composites＂ in English and Chinese, respectively. Repetitive studies and non-relevant studies were excluded. And 33 papers were included in result analsysis. RESULTS AND CONCLUSION： With the development of nanotechnology, components of nano-hydroxyapatite composites are optimized. Experimental results have showed their superiority that nano-hydroxyapatite composites could mimic natural bone and extracellular matrix well. Simultaneously, the preparation method needs further optimization, the combination between nano-hydroxyapatite and polymer need to be improved so as that nano-hydroxyapatite composites have the best mechanical property, best processability and best biological property, then meeting the requirements of clinical applications.