可降解医用膜预防硬膜外粘连的研究概况

Degradable medical films for prevention of epidural adhesion

背景:预防硬膜外粘连的方法很多,而可降解医用膜因为其独特的性质,在未来有着良好的应用前景。目的:概括、总结可降解医用膜的优缺点及实验应用效果。方法:应用计算机检索2001-01/2011-01PubMed数据库、中国知网数据库相关文章,中文检索词为"椎板切除术,可降解医用膜,硬膜粘连",英文检索词为"Laminectomy,degradable medical films,epidural adhesion"。排除重复文献,筛选纳入28篇文献进行综述。结果及结论:可降解医用膜能很好的预防硬膜外粘连,并且其降解产物可被人体吸收或通过呼吸及体液排出体外,故不会对人体产生危害,可作为预防硬膜外粘连的理想的材料。可降解医用膜众多,实验结果也不尽相同,由于单一种医用膜都各自存在缺点,将两种或两种以上膜进行改性后可克服各自身的缺点,是未来研究的方向。

BACKGROUND： There are many methods for preventing epidural adhesion. Because of the unique properties, gradable medical films have a good application prospect in the future. OBJECTIVE： To summarize the advantages, disadvantages and clinical effects of biodegradable medical films. METHODS： A computer-based online search was performed on PuMed and CNKI databases with Keywords ＂Laminectomy, degradable medical films, epidural adhesion＂ in English and Chinese from January 2001 to January 2011. Repeated literatures were eliminated, and 28 articles were included. RESULTS AND CONCLUSION： Biodegradable medical films can prevent epidural adhesion effectively, and their products can be absorbed by human body or discharged with breath and body fluids, which cannot cause harm to human body. Therefore, these films can be the ideal materials for preventing epidural adhesion. The biodegradable medical films are numerous, and experimental results are also different. Because shortcomings of a single kind of medical film, the modified film with two or more films can overcome the shortcomings, and there is a broad prospect in clinical trials in the future.