镁合金作为生物医用植入材料的临床应用

Magnesium alloys act as biomedical implant materials

背景:镁合金由于其良好的生物相容性,可降解性等突出优点,在生物植入材料,尤其是作为可降解硬组织植入材料领域展示了良好的应用前景。而过快的降解速度是其投入临床应用亟待解决的关键问题。目的:对近期相关文献的综合分析归纳,对镁合金作为医用植入材料的优缺点进行了综述,对生物医用镁合金材料研究的最新进展进行了总结。方法:以"magnesium;magnesium calcium alloy;biodegradable;biomaterials"及"镁;镁钙合金;可降解;生物医用材料"为关键词检索ScienceDirect数据库和中国期刊全文数据库。纳入与镁合金生物医用材料密切相关文献,保留34篇文献做进一步分析。结果与结论:镁钙及镁钙基合金是未来生物医用植入材料重要的发展方向之一,快速凝固工艺是有效改善镁合金降解速度过快问题的新方法;计算模拟方法应用于镁合金生物材料有可能从微观角度深入理解镁合金用于生物医用植入材料的相关问题;另一方面,国内镁合金生物材料研究急需从基础向临床转化。

BACKGROUND： Magnesium alloys have good application prospect in the biomedical implant material, especially, in the degradable hard issue implant material areas with prominent superiorities, such as good biocompatibility and biodegradability. However, their high corrosion rate is the key disadvantage desiderated to be improved before their application in clinic. OBJECTIVE： To summarize the advantages and disadvantages of magnesium alloys as medical implant materials and to conclude the latest progress of magnesium alloys as biomedical implant materials. METHODS： ScienceDirect and CNKI databases were searched by using the Keywords of ＂magnesium; magnesium calcium alloy; biodegradable; biomaterials＂ in English and Chinese for relevant articles about magnesium alloys as biomedical implant materials. Finally, 34 articles were included. RESULTS AND CONCLUSION： Magnesium calcium and its alloys are one of the development directions of biomedical implant materials; and the rapid solidification technique is a promising method to improve the corrosion property of magnesium alloys; it can get insight into the microscopic mechanisms of magnesium alloys as implant materials with computer simulation methods; in addition, the theory study of magnesium alloys needs to translate to clinical study and impel its clinical application as soon as possible.